Edoxaban in elderly patient with morbid obesity and atrial fibrillation: the role of plasma levels evaluation for selecting the appropriate dose

We present the case of a 80-year-old man with atrial fibrillation, morbid obesity (weight 123 kg, height 167 cm, BMI 44.1), high clearance of creatinine and pharmacological polytherapy, in which the serial determinations of edoxaban plasma levels help us to choose the appropriate dose.

Saved in:
Bibliographic Details
Published in:Monaldi archives for chest disease 2020-03, Vol.90 (1)
Main Authors: Russo, Vincenzo, Rago, Anna, Laezza, Nunzia, Di Micco, Pierpaolo, Giannetti, Laura, Atripaldi, Luigi, D'Onofrio, Antonio, Golino, Paolo, Nigro, Gerardo
Format: Article
Language:English
Subjects:
Aged, 80 and over
Anticoagulants - administration & dosage
Anticoagulants - pharmacokinetics
atrial fibrillation
Atrial Fibrillation - complications
Atrial Fibrillation - drug therapy
Drug Therapy, Combination
edoxaban
elderly
Humans
Male
non-vitamin k oral anticoagulant
obesity
Obesity, Morbid - complications
plasma levels
Pyridines - administration & dosage
Pyridines - pharmacokinetics
Thiazoles - administration & dosage
Thiazoles - pharmacokinetics
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We present the case of a 80-year-old man with atrial fibrillation, morbid obesity (weight 123 kg, height 167 cm, BMI 44.1), high clearance of creatinine and pharmacological polytherapy, in which the serial determinations of edoxaban plasma levels help us to choose the appropriate dose.
ISSN:1122-0643
2532-5264
DOI:10.4081/monaldi.2020.1224