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Edoxaban in elderly patient with morbid obesity and atrial fibrillation: the role of plasma levels evaluation for selecting the appropriate dose

We present the case of a 80-year-old man with atrial fibrillation, morbid obesity (weight 123 kg, height 167 cm, BMI 44.1), high clearance of creatinine and pharmacological polytherapy, in which the serial determinations of edoxaban plasma levels help us to choose the appropriate dose.

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Published in:Monaldi archives for chest disease 2020-03, Vol.90 (1)
Main Authors: Russo, Vincenzo, Rago, Anna, Laezza, Nunzia, Di Micco, Pierpaolo, Giannetti, Laura, Atripaldi, Luigi, D'Onofrio, Antonio, Golino, Paolo, Nigro, Gerardo
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container_title Monaldi archives for chest disease
container_volume 90
creator Russo, Vincenzo
Rago, Anna
Laezza, Nunzia
Di Micco, Pierpaolo
Giannetti, Laura
Atripaldi, Luigi
D'Onofrio, Antonio
Golino, Paolo
Nigro, Gerardo
description We present the case of a 80-year-old man with atrial fibrillation, morbid obesity (weight 123 kg, height 167 cm, BMI 44.1), high clearance of creatinine and pharmacological polytherapy, in which the serial determinations of edoxaban plasma levels help us to choose the appropriate dose.
doi_str_mv 10.4081/monaldi.2020.1224
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subjects Aged, 80 and over
Anticoagulants - administration & dosage
Anticoagulants - pharmacokinetics
atrial fibrillation
Atrial Fibrillation - complications
Atrial Fibrillation - drug therapy
Drug Therapy, Combination
edoxaban
elderly
Humans
Male
non-vitamin k oral anticoagulant
obesity
Obesity, Morbid - complications
plasma levels
Pyridines - administration & dosage
Pyridines - pharmacokinetics
Thiazoles - administration & dosage
Thiazoles - pharmacokinetics
title Edoxaban in elderly patient with morbid obesity and atrial fibrillation: the role of plasma levels evaluation for selecting the appropriate dose
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