Effect of non-surgical periodontal treatment on three salivary adipokines in diabetic patients with periodontitis

This study investigated the effect of non-surgical periodontal treatment on clinical indices and salivary levels of visfatin, chemerin, and progranulin in diabetic patients with periodontitis. This interventional clinical trial was performed on 20 patients with type II diabetes mellitus (T2DM) with...

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Bibliographic Details
Published in:Journal of dental research, dental clinics, dental prospects dental clinics, dental prospects, 2020-01, Vol.14 (3), p.199-205
Main Authors: Ziaei, Narges, Golmohammadi, Shima, Ataee, Mari, Ardalani, Farnoosh, Mesgari Abbasi, Mehran
Format: Article
Language:English
Subjects:
adipokines
human chemerin protein
non-surgical periodontal debridement
Original
periodontitis
progranulin
type 2 diabetes mellitus
visfatin
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Summary:This study investigated the effect of non-surgical periodontal treatment on clinical indices and salivary levels of visfatin, chemerin, and progranulin in diabetic patients with periodontitis. This interventional clinical trial was performed on 20 patients with type II diabetes mellitus (T2DM) with moderate to severe chronic periodontitis (periodontitis stages II or III according to the new classification of periodontal diseases). Clinical indices, including gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL) and plaque index (PI), were recorded and visfatin, chemerin, and progranulin adipokines levels were also measured in unstimulated saliva by ELISA technique at baseline and twelve weeks after non-surgical periodontal treatment. GI dropped from 1.92±0.27 to 0.71±0.14 after the intervention (P
ISSN:2008-210X
2008-2118
DOI:10.34172/joddd.2020.029