Initial Muscle Quality Affects Individual Responsiveness of Interleukin-6 and Creatine Kinase following Acute Eccentric Exercise in Sedentary Obese Older Women

This study aimed to evaluate the time course and responsiveness of plasma interleukin-6 (IL-6) and creatine kinase (CK) levels following acute eccentric resistance exercise in sedentary obese older women with a different muscle quality index (MQI). Eighty-eight participants (69.4 ± 6.06 years) compl...

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Bibliographic Details
Published in:Biology (Basel, Switzerland) Switzerland), 2022-03, Vol.11 (4), p.537
Main Authors: de Sousa Neto, Ivo Vieira, da Cunha Nascimento, Dahan, Prestes, Jonato, da Fonseca, Eduardo Fernandes, Celes, Rodrigo Souza, Rolnick, Nicholas, de Sousa Barbalho, Yuri Gustavo, Silva, Alessandro de Oliveira, Stival, Marina Morato, de Lima, Luciano Ramos, Funghetto, Silvana Schwerz
Format: Article
Language:English
Subjects:
Adaptation
Aging
Body composition
Body fat
Body mass index
Creatine
Creatine kinase
Cytokines
eccentric training
Energy balance
Exercise
Geriatrics
Homeostasis
Interleukin 6
Laboratories
muscle
Muscle strength
Musculoskeletal system
Obesity
Older people
Phenotypes
physical activity
Physical fitness
Physiology
responders
Sarcopenia
Womens health
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Summary:This study aimed to evaluate the time course and responsiveness of plasma interleukin-6 (IL-6) and creatine kinase (CK) levels following acute eccentric resistance exercise in sedentary obese older women with a different muscle quality index (MQI). Eighty-eight participants (69.4 ± 6.06 years) completed an acute eccentric resistance exercise (7 sets of 10 repetitions at 110% of 10-repetition maximum with 3 min rest interval). Participants were divided into two groups: high or low MQI according to 50th percentile cut-off. The responsiveness was based on minimal clinical important difference. There were no differences between groups and time on IL-6 and CK levels (p > 0.05). However, the high MQI group displayed a lower proportion of low responders (1 for laboratory and 2 for field-based vs. 5 and 4) and a higher proportion of high responders for IL-6 (7 for laboratory and 6 for field-based vs. 4 and 5) compared to low MQI group. In addition, the high MQI group showed a higher proportion of high responders for CK (11 for laboratory and 9 for field-based vs. 6 and 6) compared to low MQI. A prior MQI screening can provide feedback to understand the magnitude response. Individual responsiveness should be taken into consideration for maximizing eccentric exercise prescription.
ISSN:2079-7737
2079-7737
DOI:10.3390/biology11040537