A Gambogic Acid-Loaded Delivery System Mediated by Ultrasound-Targeted Microbubble Destruction: A Promising Therapy Method for Malignant Cerebral Glioma

The blood-brain barrier (BBB) inhibits the delivery of macromolecular chemotherapeutic drugs to brain tumors, leading to low utilization rates and toxic side effects to surrounding tissues and organs. Ultrasonic targeted microbubble destruction (UTMD) technology can open the BBB, leading to a new ty...

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Bibliographic Details
Published in:International journal of nanomedicine 2022-01, Vol.17, p.2001-2017
Main Authors: Dong, Lei, Li, Nana, Wei, Xixi, Wang, Yongling, Chang, Liansheng, Wu, Hongwei, Song, Liujiang, Guo, Kang, Chang, Yuqiao, Yin, Yaling, Pan, Min, Shen, Yuanyuan, Wang, Feng
Format: Article
Language:English
Subjects:
Animals
Blood-Brain Barrier - metabolism
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - drug therapy
Brain Neoplasms - metabolism
Brain tumors
Cancer
cavitation effect
Chemotherapy
Dielectric films
Drug delivery systems
Drug Delivery Systems - methods
Drugs
focused ultrasound
glioblastoma
Glioblastoma - drug therapy
Glioma - diagnostic imaging
Glioma - drug therapy
Glioma - metabolism
Gliomas
Methods
Mice
Microbubbles
Original Research
Thin films
Vehicles
Xanthones
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Summary:The blood-brain barrier (BBB) inhibits the delivery of macromolecular chemotherapeutic drugs to brain tumors, leading to low utilization rates and toxic side effects to surrounding tissues and organs. Ultrasonic targeted microbubble destruction (UTMD) technology can open the BBB, leading to a new type of drug delivery system with particular utility in glioma. We have developed a new type of drug-loaded microbubble complex based on poly(lactic-co-glycolic acid) (PLGA) that targets gambogic acid (GA) to the area of brain tumors through UTMD. GA/PLGA nanoparticles were prepared by the double emulsification method, and cationic microbubbles (CMBs) were prepared by a thin film hydration method. The GA/PLGA-CMB microbubble complex was assembled through electrostatic attractions and was characterized chemically. The anti-glioblastoma effect of GA/PLGA-CMB combined with focused ultrasound (FUS) was evaluated by biochemical and imaging assays in cultured cells and model mice. GA/PLGA-CMB combined with FUS demonstrated a significant inhibitory effect on glioblastoma cell lines U87 and U251 as compared with controls (P
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/IJN.S344940