The Crosstalk between Myeloid Derived Suppressor Cells and Immune Cells: To Establish Immune Tolerance in Transplantation

Myeloid derived suppressor cells (MDSCs) are a heterogeneous population of myeloid precursor and progenitor cells and endowed with a robust immunosuppressive activity in multiple pathophysiological conditions. Recent studies have uncovered the crosstalk between MDSCs and immune cells (i.e., natural...

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Bibliographic Details
Published in:Journal of immunology research 2016-01, Vol.2016 (2016), p.1-6
Main Authors: Rong, Ruiming, Yang, Cheng, Wang, Shuo, Zhang, Chao
Format: Article
Language:English
Subjects:
Adaptive Immunity
Animals
Antigens
Cell growth
Cytokines
Cytotoxicity
Dendritic cells
Dendritic Cells - immunology
Humans
Immunology
Investigations
Killer Cells, Natural - immunology
Lymphocytes
Macrophages - immunology
Mice
Myeloid-Derived Suppressor Cells - immunology
Natural Killer T-Cells - immunology
Receptor Cross-Talk - immunology
Review
Rodents
Skin
Stem cells
T cell receptors
T-Lymphocytes, Regulatory - immunology
Transplantation Tolerance
Transplants & implants
Tumor necrosis factor-TNF
Vascular endothelial growth factor
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Summary:Myeloid derived suppressor cells (MDSCs) are a heterogeneous population of myeloid precursor and progenitor cells and endowed with a robust immunosuppressive activity in multiple pathophysiological conditions. Recent studies have uncovered the crosstalk between MDSCs and immune cells (i.e., natural killer cells, dendritic cells, macrophages, natural killer T cells, and regulatory T cells) and its role in the establishment and maintenance of immune tolerant microenvironment in transplantation. Considering their strong immunosuppressive capability, MDSCs could become a prospective clinical regimen during transplantation tolerance induction, resulting in long-term graft survival with decreased or without immunosuppressive drugs. The review summarized recent research advances in this field and looked ahead at the research directions in the future.
ISSN:2314-8861
2314-7156
DOI:10.1155/2016/4986797