Involvement of Reduced Microbial Diversity in Inflammatory Bowel Disease

A considerable number of studies have been conducted to study the microbial profiles in inflammatory conditions. A common phenomenon in inflammatory bowel disease (IBD) is the reduction of the diversity of microbiota, which demonstrates that microbial diversity negatively correlates with disease sev...

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Bibliographic Details
Published in:Gastroenterology research and practice 2016-01, Vol.2016 (2016), p.1-7
Main Authors: Yu, Xinjuan, Wang, Lili, Gong, Xiaojie, Gong, Dawei, Dong, Quanjiang
Format: Article
Language:English
Subjects:
Bile
Biodiversity
Biological diversity
Biosynthesis
Crohn's disease
Development and progression
Ecosystems
Eczema
Feces
Inflammation
Inflammatory bowel disease
Inflammatory bowel diseases
Inflammatory diseases
Metabolism
Microbiota (Symbiotic organisms)
Pathogenesis
Review
Siblings
Studies
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Summary:A considerable number of studies have been conducted to study the microbial profiles in inflammatory conditions. A common phenomenon in inflammatory bowel disease (IBD) is the reduction of the diversity of microbiota, which demonstrates that microbial diversity negatively correlates with disease severity in IBD. Increased microbial diversity is known to occur in disease remission. Species diversity plays an important role in maintaining the stability of the intestinal ecosystem as well as normal ecological function. A reduction in microbial diversity corresponds to a decrease in the stability of the ecosystem and can impair ecological function. Fecal microbiota transplantation (FMT), probiotics, and prebiotics, which aim to modulate the microbiota and restore its normal diversity, have been shown to be clinically efficacious. In this study, we hypothesized that a reduction in microbial diversity could play a role in the development of IBD.
ISSN:1687-6121
1687-630X
DOI:10.1155/2016/6951091