Changes in neuronal activation patterns in response to androgen deprivation therapy: a pilot study

A common treatment option for men with prostate cancer is androgen deprivation therapy (ADT). However, men undergoing ADT may experience physical side effects, changes in quality of life and sometimes psychiatric and cognitive side effects. In this study, hormone naïve patients without evidence of m...

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Bibliographic Details
Published in:BMC cancer 2010-01, Vol.10 (1), p.1-1, Article 1
Main Authors: Cherrier, Monique M, Borghesani, Paul R, Shelton, Amy L, Higano, Celestia S
Format: Article
Language:English
Subjects:
Aged
Androgen Antagonists - adverse effects
Androgens
Androgens - metabolism
Bone density
Brain
Brain - pathology
Care and treatment
Cognition
Cognition & reasoning
Diagnosis
Health aspects
Hormone therapy
Humans
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medical research
Memory
Mental Recall
Middle Aged
Neurons - metabolism
Pilot Projects
Prostate cancer
Prostatic Neoplasms - drug therapy
Prostatic Neoplasms - pathology
Quality of Life
Space Perception
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Summary:A common treatment option for men with prostate cancer is androgen deprivation therapy (ADT). However, men undergoing ADT may experience physical side effects, changes in quality of life and sometimes psychiatric and cognitive side effects. In this study, hormone naïve patients without evidence of metastases with a rising PSA were treated with nine months of ADT. Functional magnetic resonance imaging (fMRI) of the brain during three visuospatial tasks was performed at baseline prior to treatment and after nine months of ADT in five subjects. Seven healthy control patients, underwent neuroimaging at the same time intervals. ADT patients showed reduced, task-related BOLD-fMRI activation during treatment that was not observed in control subjects. Reduction in activation in right parietal-occipital regions from baseline was observed during recall of the spatial location of objects and mental rotation. Findings, while preliminary, suggest that ADT reduces task-related neural activation in brain regions that are involved in mental rotation and accurate recall of spatial information.
ISSN:1471-2407
1471-2407
DOI:10.1186/1471-2407-10-1