Co-Administration of Injected and Oral Vaccine Candidates Elicits Improved Immune Responses over Either Route Alone

Infectious diseases continue to be a significant cause of morbidity and mortality, and although efficacious vaccines are available for many diseases, some parenteral vaccines elicit little or no mucosal antibodies which can be a significant problem since mucosal tissue is the point of entry for 90%...

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Bibliographic Details
Published in:Vaccines (Basel) 2020-01, Vol.8 (1), p.37
Main Authors: Hayden, Celine A, Landrock, Danilo, Hung, Chiung Yu, Ostroff, Gary, Fake, Gina M, Walker, John H, Kier, Ann, Howard, John A
Format: Article
Language:English
Subjects:
bioencapsulation
Dosage and administration
Immune response
immunogenicity
maize oral vaccine
mucosal
Observations
Oral vaccines
Patient outcomes
plant vaccine
subunit vaccine
supercritical fluid extraction
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Summary:Infectious diseases continue to be a significant cause of morbidity and mortality, and although efficacious vaccines are available for many diseases, some parenteral vaccines elicit little or no mucosal antibodies which can be a significant problem since mucosal tissue is the point of entry for 90% of pathogens. In order to provide protection for both serum and mucosal areas, we have tested a combinatorial approach of both parenteral and oral administration of antigens for diseases caused by a viral pathogen, Hepatitis B, and a fungal pathogen, . We demonstrate that co-administration by the parenteral and oral routes is a useful tool to increase the overall immune response. This can include achieving an immune response in tissues that are not elicited when using only one route of administration, providing a higher level of response that can lead to fewer required doses or possibly providing a better response for individuals that are considered poor or non-responders.
ISSN:2076-393X
2076-393X
DOI:10.3390/vaccines8010037