Syrian hamster as an ideal animal model for evaluation of cancer immunotherapy

Cancer immunotherapy (CIT) has emerged as an exciting new pillar of cancer treatment. Although benefits have been achieved in individual patients, the overall response rate is still not satisfactory. To address this, an ideal preclinical animal model for evaluating CIT is urgently needed. Syrian ham...

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Bibliographic Details
Published in:Frontiers in immunology 2023-02, Vol.14, p.1126969
Main Authors: Jia, Yangyang, Wang, Yanru, Dunmall, Louisa S Chard, Lemoine, Nicholas R, Wang, Pengju, Wang, Yaohe
Format: Article
Language:English
Subjects:
adoptive cell therapy
Animals
cancer immunotherapy
Cricetinae
cytokine
Cytokines
Humans
immune checkpoint inhibitor
Immunology
Immunotherapy
Mesocricetus
Models, Animal
Neoplasms - therapy
Oncolytic Viruses - physiology
Syrian hamster
tumor model
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Summary:Cancer immunotherapy (CIT) has emerged as an exciting new pillar of cancer treatment. Although benefits have been achieved in individual patients, the overall response rate is still not satisfactory. To address this, an ideal preclinical animal model for evaluating CIT is urgently needed. Syrian hamsters present similar features to humans with regard to their anatomy, physiology, and pathology. Notably, the histological features and pathological progression of tumors and the complexity of the tumor microenvironment are equivalent to the human scenario. This article reviews the current tumor models in Syrian hamster and the latest progress in their application to development of tumor treatments including immune checkpoint inhibitors, cytokines, adoptive cell therapy, cancer vaccines, and oncolytic viruses. This progress strongly advocates Syrian hamster as an ideal animal model for development and assessment of CIT for human cancer treatments. Additionally, the challenges of the Syrian hamster as an animal model for CIT are also discussed.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1126969