Circulating microaggregates as biomarkers for the Post‐COVID syndrome

CoVID-19 can develop into Post-COVID syndrome of potentially high morbidity, with procoagulation and reactivation of dormant viral infections being hypothesized pathophysiological mechanisms. We report on a patient suffering from fatigue, post exertional malaise, pain and neurological symptoms as a...

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Bibliographic Details
Published in:IDCases 2024, Vol.36, p.e02000, Article e02000
Main Authors: Hermann, M., Lisch, C., Gerth, R., Wick, G., Fries, D., Wick, N.
Format: Article
Language:English
Subjects:
Chronic fatigue
Coagulation
Post-CoVID
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Summary:CoVID-19 can develop into Post-COVID syndrome of potentially high morbidity, with procoagulation and reactivation of dormant viral infections being hypothesized pathophysiological mechanisms. We report on a patient suffering from fatigue, post exertional malaise, pain and neurological symptoms as a consequence of the second CoVID infection. Using live confocal microscopy on native whole blood samples we detected microaggregates of thrombocytes, leukocytes and plasma proteins in peripheral blood. In addition, there was specific cellular immunological reactivity to EBV. Upon anticoagulatory and virustatic pharmacological therapy we observed dissolution of microaggregates and significant stable clinical remission. We suggest to consider circulating microaggregates as a morphological indicator of chronic post-COVID syndrome.
ISSN:2214-2509
2214-2509
DOI:10.1016/j.idcr.2024.e02000