Association of carotid atherosclerotic plaque and intima-media thickness with the monocyte to high-density lipoprotein cholesterol ratio among low-income residents of rural China: a population-based cross-sectional study

• Published in: BMC public health 2023-12, Vol.23 (1), p.2541-2541, Article 2541
• Main Authors: Zhang, Zhen, Gao, Yannan, Li, Zejian, Li, Bingyi, Gao, Shuai, Sun, Jiayi, Tu, Jun, Ning, Xianjia, Zhang, Wenjuan, Wang, Jinghua
• Format: Article
• Language: English
• Subjects: Aged; Alcohol; Analysis; Arteriosclerosis; Atherosclerosis; Atherosclerotic plaque; Biomarkers; Blood; Body mass index; Cardiovascular disease; Care and treatment; Carotid arteries; Carotid Arteries - diagnostic imaging; Carotid artery; Carotid Artery Diseases - diagnostic imaging; Carotid Artery Diseases - epidemiology; Carotid Atherosclerosis; Carotid Intima-Media Thickness; Cerebrovascular diseases; Cholesterol; Cholesterol, HDL; Cross-Sectional Studies; Diabetes; Diagnosis; Epidemiology; Female; Gender; Health aspects; Heart rate; High density; High density lipoprotein; Humans; Hypertension; Intima-media thickness; Laboratories; Lipoproteins; Low income groups; Measurement; Medical screening; Methods; Middle Aged; Missing data; Monocytes; Multivariate analysis; Per capita; Performance prediction; Plaque, Atherosclerotic; Population studies; Ratio of monocyte to high-density lipoprotein cholesterol; Regression analysis; Residential density; Response rates; Risk Factors; Rural areas; Smoking; Stroke; Thickness; Ultrasonic imaging; Urban areas; Vascular diseases
• ISSN: 1471-2458; 1471-2458
• DOI: 10.1186/s12889-023-17447-0

The monocytes to high-density lipoprotein cholesterol ratio (MHR) has been identified as a potential biomarker for cardiovascular and cerebrovascular diseases. In this population-based cross-sectional study, we explored the relationships among carotid artery disease (CAD), including the presence of carotid atherosclerotic plaque (CAP) and carotid artery intima-media thickness (CIMT), the MHR, and related parameter changes. This cross-sectional study, Conducted from April to June 2019 in a rural area of Tianjin, involved middle-aged and elderly participants. Based on carotid ultrasound examinations, participants were divided into CAP and non-CAP groups. Logistic regression and Receiver Operating Characteristic (ROC) curve analyses were utilized to assess MHR's predictive value for CAP. Gender-specific analyses were also performed to examine predictive variations. The relationship between CIMT and MHR was evaluated using linear regression. Of the 2109 participants meeting the inclusion criteria, 51.6% were identified with CAP. Multivariate analysis revealed a significant association between MHR and CAP prevalence, (OR, 9.670; 95% CI, 2.359-39.631; P = 0.002), particularly in females (OR, 5.921; 95% CI, 1.823-19.231; P = 0.003), after adjusting for covariates. However, no significant correlation was found between CIMT and MHR when adjusted for other factors. The ROC analysis showed the area under the curve for MHR and CAP to be 0.569 (95% CI: 0.544-0.593; P