Primary NK/T cell lymphoma nasal type of the colon

Since nasal NK/T-cell lymphoma and NK/T-cell lymphoma nasal type are rare diseases, colonic involvement has seldom been seen. We report a case of a patient with a primary NK/T-cell lymphoma nasal type of the colon. The patient had no history of malignant diseases and was diagnosed after exhaustive s...

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Bibliographic Details
Published in:Rare tumors 2013-03, Vol.5 (1), p.e9-37
Main Authors: Mahuad, Carolina Valeria, Bilbao, Erica Rojas, Garate, Gonzalo Martín, de Los Ángeles Vicente Repáraz, María, Del Olmo, Mercedes, Casali, Claudia Érica, Zerga, Marta Elisa, Chirife, Ana María, Cicco, Juan Alberto
Format: Article
Language:English
Subjects:
Case Report
lymphoma, extranodal NK-T-cell, L-asparaginase, intestinal lymphoma
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Summary:Since nasal NK/T-cell lymphoma and NK/T-cell lymphoma nasal type are rare diseases, colonic involvement has seldom been seen. We report a case of a patient with a primary NK/T-cell lymphoma nasal type of the colon. The patient had no history of malignant diseases and was diagnosed after exhaustive study in the context of fever of unknown origin. The first therapeutic approach followed the DA-EPOCH-protocol: etoposide, prednisone, doxor-rubicin, vincristine and cyclophosphamide. The persistence of constitutional symptoms after the first treatment course motivated the switch to a second line following the SMILE-protocol: dexamethasone, metotrexate, ifosfamide, E.coli L-asparaginase, and etoposide. Despite intensive chemotherapy, the patient died 2 months after the diagnose of an extranodal NK/T-cell lymphoma of the colon and 4 months after the first symptomatic appearance of disease.
ISSN:2036-3605
2036-3613
2036-3613
DOI:10.4081/rt.2013.e9