A transient benign lymph node-based proliferation of T-cells simulating non-Hodgkin lymphoma in a patient with psoriasis treated with tumor necrosis factor alpha and CD11a antagonists

Therapeutic biologic agents are uncommonly associated with lymphoma. We report a patient with psoriasis treated with the biologic agents efalizumab (Raptiva) and etanercept (Enbrel), who developed painless lymphadenopathy with peripheral lymphocytosis during treatment, simulating a non-Hodgkin lymph...

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Bibliographic Details
Published in:Diagnostic pathology 2008-03, Vol.3 (1), p.13-13, Article 13
Main Authors: Hurley, M Yadira, George, Mary Noel, Leonardi, Craig L, Frater, John L
Format: Article
Language:English
Subjects:
Case Report
Causes of
Development and progression
Health aspects
Hodgkin's disease
Physiological aspects
T cells
Tumor necrosis factor
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Summary:Therapeutic biologic agents are uncommonly associated with lymphoma. We report a patient with psoriasis treated with the biologic agents efalizumab (Raptiva) and etanercept (Enbrel), who developed painless lymphadenopathy with peripheral lymphocytosis during treatment, simulating a non-Hodgkin lymphoma clinically and pathologically. Lymphocytosis and lymphadenopathy spontaneously remitted following cessation of etanercept therapy and have not recurred. Distinction between clinically benign lymphoid proliferations related to anti-psoriasis therapy and malignant lymphoma avoids the unnecessary use of anti-lymphoma chemotherapy.
ISSN:1746-1596
1746-1596
DOI:10.1186/1746-1596-3-13