P2RX7 Gene rs1718125 Polymorphism is Related with Postoperative Pain and Fentanyl Intake in Esophageal Cancer Patients

Prevention and control of postoperative pains are essential, which affects the prognosis and life quality of patients. Fentanyl is a widely used opioid drug for pre-, intra- and postoperative analgesia. Identifying a patient's genotype before surgery may help to control the fentanyl dose in the...

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Bibliographic Details
Published in:Pharmacogenomics and personalized medicine 2020-01, Vol.13, p.585-589
Main Authors: Zheng, Cuijuan, Wang, Jiayu, Xie, Shouxiang
Format: Article
Language:English
Subjects:
Analgesia
Analgesics
Cancer therapies
Chemotherapy
Deoxyribonucleic acid
DNA
Drug dosages
Esophageal cancer
Esophagus
Fentanyl
Gene polymorphism
Genotype & phenotype
Genotyping
Lung cancer
Medical prognosis
Narcotics
Neurosciences
Opioids
Original Research
p2rx7
Pain
Pain perception
Patients
Polymerase chain reaction
Polymorphism
postoperative pain
Postoperative period
Quality of life
single nucleotide polymorphism
Surgery
Surgical outcomes
Variance analysis
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Summary:Prevention and control of postoperative pains are essential, which affects the prognosis and life quality of patients. Fentanyl is a widely used opioid drug for pre-, intra- and postoperative analgesia. Identifying a patient's genotype before surgery may help to control the fentanyl dose in the perioperative period. This study enrolling 645 esophageal cancer (EC) patients was aimed to investigate the associations of gene rs1718125 polymorphism with fentanyl intake and postoperative pains in a Chinese Han population. Genotyping was accomplished by direct sequencing and polymerase chain reaction. The GA/AA genotype carriers showed lower visual analog scale scores at postoperative 0, 6 and 24 h, but not at 48 h, compared with the GG genotype. The fentanyl consumption of GG genotype was remarkably more relative to the GA/AA genotype at 6 and 24 h after treatment. rs1718125 polymorphism is connected to the postoperative pains and fentanyl use for EC patients.
ISSN:1178-7066
1178-7066
DOI:10.2147/PGPM.S252798