Autoimmune atrophic gastritis: current perspectives

At present there is no universally accepted classification for gastritis. The first successful classification (The Sydney System) that is still commonly used by medical professionals was first introduced by Misiewicz et al in Sydney in 1990. In fact, it was the first detailed classification after th...

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Bibliographic Details
Published in:Clinical and Experimental Gastroenterology 2017-01, Vol.10, p.19-27
Main Authors: Minalyan, Artem, Benhammou, Jihane N, Artashesyan, Aida, Lewis, Michael S, Pisegna, Joseph R
Format: Article
Language:English
Subjects:
Analysis
Anemia
Autoimmune gastritis
Biopsy
Care and treatment
Diagnosis
Epidemiology
Etiology
Gastric cancer
Gastric Carcinoid
Gastritis
Gastroenterology
Immunoglobulins
Infections
Medical research
Mucous membrane
Neuroendocrine tumors
Pathogenesis
Pernicious Anemia
Review
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Summary:At present there is no universally accepted classification for gastritis. The first successful classification (The Sydney System) that is still commonly used by medical professionals was first introduced by Misiewicz et al in Sydney in 1990. In fact, it was the first detailed classification after the discovery of by Warren and Marshall in 1982. In 1994, the Updated Sydney System was proposed during the International Workshop on the Histopathology of Gastritis followed by the publication in by Dixon et al. Using the new classification, distinction between atrophic and nonatrophic gastritis was revised, and the visual scale grading was incorporated. According to the Updated Sydney System Classification, atrophic gastritis is categorized into multifocal ( , environmental factors, specific diet) and corpus-predominant (autoimmune). Since metaplasia is a key histological characteristic in patients with atrophic gastritis, it has been recommended to use the word "metaplastic" in both variants of atrophic gastritis: autoimmune metaplastic atrophic gastritis (AMAG) and environmental metaplastic atrophic gastritis. Although there are many overlaps in the course of the disease and distinction between those two entities may be challenging, the aim of this review article was to describe the etiology, epidemiology, pathogenesis, diagnosis, clinical manifestations and treatment in patients with AMAG. However, it is important to mention that is the most common etiologic factor for the development of gastritis in the world.
ISSN:1178-7023
1178-7023
DOI:10.2147/ceg.s109123