Guardians under Siege: Exploring Pollution's Effects on Human Immunity

Chemical pollution poses a significant threat to human health, with detrimental effects on various physiological systems, including the respiratory, cardiovascular, mental, and perinatal domains. While the impact of pollution on these systems has been extensively studied, the intricate relationship...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-07, Vol.25 (14), p.7788
Main Authors: Drago, Gaspare, Aloi, Noemi, Ruggieri, Silvia, Longo, Alessandra, Contrino, Maria Lia, Contarino, Fabio Massimo, Cibella, Fabio, Colombo, Paolo, Longo, Valeria
Format: Article
Language:English
Subjects:
Chemicals
Chronic illnesses
Climate change
developmental toxicology
Diabetes
Disease
DNA methylation
environmental pollutant
Epigenetics
Gene expression
Genotype & phenotype
Heavy metals
Hydrocarbons
Immune system
immunomodulation
Inflammation
innate and adaptive immunity
Metabolism
Metabolites
Oxidative stress
Pollutants
pregnancy
Toxicity
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Summary:Chemical pollution poses a significant threat to human health, with detrimental effects on various physiological systems, including the respiratory, cardiovascular, mental, and perinatal domains. While the impact of pollution on these systems has been extensively studied, the intricate relationship between chemical pollution and immunity remains a critical area of investigation. The focus of this study is to elucidate the relationship between chemical pollution and human immunity. To accomplish this task, this study presents a comprehensive review that encompasses in vitro, ex vivo, and in vivo studies, shedding light on the ways in which chemical pollution can modulate human immunity. Our aim is to unveil the complex mechanisms by which environmental contaminants compromise the delicate balance of the body's defense systems going beyond the well-established associations with defense systems and delving into the less-explored link between chemical exposure and various immune disorders, adding urgency to our understanding of the underlying mechanisms and their implications for public health.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25147788