Association of Behçet disease with psoriasis and psoriatic arthritis

Behçet disease (BD) is a debilitating multi-systemic vasculitis with a litany of muco-cutaneous manifestations and potentially lethal complications. Meanwhile, psoriasis (PSO) is a cutaneous and systemic inflammatory disorder marked by hyperplastic epidermis and silvery scales, which may be accompan...

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Bibliographic Details
Published in:Scientific reports 2021-01, Vol.11 (1), p.2531-2531, Article 2531
Main Authors: Hahn, Hyung Jin, Kwak, Sang Gyu, Kim, Dong-Kyu, Kim, Jong-Yeup
Format: Article
Language:English
Subjects:
692/420/256/2515
692/420/2780/2152/1566
Age
Arthritis
Behcet's syndrome
Body weight
Epidermis
Humanities and Social Sciences
Inflammatory diseases
multidisciplinary
Psoriasis
Psoriatic arthritis
Science
Science (multidisciplinary)
Skin diseases
Systemic vasculitis
Vein & artery diseases
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Summary:Behçet disease (BD) is a debilitating multi-systemic vasculitis with a litany of muco-cutaneous manifestations and potentially lethal complications. Meanwhile, psoriasis (PSO) is a cutaneous and systemic inflammatory disorder marked by hyperplastic epidermis and silvery scales, which may be accompanied by a distinct form of arthropathy called psoriatic arthritis (PsA). While the clinical pictures of these two are quite different, they feature some important similarities, most of which may stem from the autoinflammatory components of BD and PSO. Therefore, the aim of this study was to investigate the prospective link between BD and cutaneous and articular manifestations of psoriasis. BD, PSO, and PsA cohorts were extracted using the National Health Insurance Service of Korea database. Using χ 2 tests, prevalence of PSO and PsA with respect to BD status was analysed. Relative to non-BD individuals, those with personal history of BD were nearly three times more likely to be diagnosed with PSO. The adjusted odds ratio (aOR) was 2.36 [95% confidence interval (CI), 1.91–2.93, p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-81972-4