Molecular Epidemiology of Carbapenem-Resistant Acinetobacter baumannii From Khartoum State, Sudan

Carbapenem resistant (CRAb) is an important global pathogen contributing to increased morbidity and mortality in hospitalized patients, due to limited alternative treatment options. Nine international clonal (IC) lineages have been identified in many countries worldwide, however, data still lacks fr...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in microbiology 2021-02, Vol.12, p.628736-628736
Main Authors: Al-Hassan, Leena, Elbadawi, Hana, Osman, Einas, Ali, Sara, Elhag, Kamal, Cantillon, Daire, Wille, Julia, Seifert, Harald, Higgins, Paul G
Format: Article
Language:English
Subjects:
antibiotic resistance
cgMLST
international clones
Microbiology
NDM-1
OXA
Sudan
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Carbapenem resistant (CRAb) is an important global pathogen contributing to increased morbidity and mortality in hospitalized patients, due to limited alternative treatment options. Nine international clonal (IC) lineages have been identified in many countries worldwide, however, data still lacks from some parts of the world, particularly in Africa. We hereby present the molecular epidemiology of MDR from four hospitals in Khartoum, Sudan, collected from 2017 to 2018. Forty-two isolates were whole-genome sequenced, and subsequent molecular epidemiology was determined by core genome MLST (cgMLST), and their resistomes identified. All isolates had an array of diverse antibiotic resistance mechanisms conferring resistance to multiple classes of antibiotics. We found a predominance (88%) of IC2 (with the intrinsic OXA-66 and acquired OXA-23), and some with NDM-1. IC2 isolates were sub-divided into 4 STs separated by 5 to 431 allelic differences, and with evidence of seven transmission clusters. Isolates belonging to IC1, IC5, and IC9 were also identified. These data illustrate that MDR IC2 are widely distributed in Khartoum hospitals and are in possession of multiple antibiotic resistance determinants.
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2021.628736