Precipitating factors of bradycardia after remdesivir administration: ICU admission and cutoff value for declining heart rate

Despite increasing concerns about the association between remdesivir and bradycardia in severe coronavirus disease 2019 (COVID-19) patients receiving remdesivir, information on its clinical course and precipitating factors is limited. Our aim was to investigate possible triggers of bradycardia after...

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Published in:Journal of microbiology, immunology and infection immunology and infection, 2023-10, Vol.56 (5), p.970-976
Main Authors: Chen, Yan-Zuo, Lin, Ming-Shen, Lin, Yi-Ping, Liu, Yi-Zhan, Yang, Chia-Jui
Format: Article
Language:English
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Summary:Despite increasing concerns about the association between remdesivir and bradycardia in severe coronavirus disease 2019 (COVID-19) patients receiving remdesivir, information on its clinical course and precipitating factors is limited. Our aim was to investigate possible triggers of bradycardia after remdesivir administration. We retrieved the medical records of hospitalized severe and critical COVID-19 patients who received remdesivir from May 1, 2021 to June 30, 2021. Bradycardia was defined as two episodes of a heart rate (HR) 
ISSN:1684-1182
1995-9133
DOI:10.1016/j.jmii.2023.06.004