Evaluation of febrile neutropenia in patients undergoing hematopoietic stem cell transplantation

The aim of this study was to determine the incidence and causes of fever as a major problem contributing to transplantation related mortality among patients undergoing hematopoietic stem cell transplantation (HSCT) and evaluation of antibiotic use, according to reliable guidelines.We retrospectively...

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Bibliographic Details
Published in:Acta medica Iranica 2014, Vol.52 (1), p.38-42
Main Authors: Amini, Shahideh, Hadjibabaie, Molouk, Jahangard-Rafsanjani, Zahra, Ashuri, Asieh, Torkamandi, Hassan, Ghavamzadeh, Ardeshir
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antibiotic therapy
Febrile Neutropenia - physiopathology
Female
Hematopoietic Stem Cell Transplantation
HSCT
Humans
Male
Middle Aged
Neutropenic fever
Young Adult
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Summary:The aim of this study was to determine the incidence and causes of fever as a major problem contributing to transplantation related mortality among patients undergoing hematopoietic stem cell transplantation (HSCT) and evaluation of antibiotic use, according to reliable guidelines.We retrospectively reviewed hospital records of 195 adult patients who underwent HSCT between 2009-2011 at hematology-oncology and bone marrow transplantation research center. Baseline information and also data related to fever and neutropenia, patient's outcomes, duration of hospitalization and antibiotic use pattern were documented.A total of 195 patients were analyzed and a total of 268 febrile episodes in 180 patients were recorded (mean 1.5 episodes per patient). About 222 episodes (82%) were associated with neutropenia which one-fourth of them were without any documented infection sources. Microbiologic documents showed that the relative frequencies of gram positive and gram negative bacteria were 62.5% and 37.5%, respectively. The hospital stay duration was directly related to the numbers of fever episodes (P
ISSN:0044-6025
1735-9694