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Exercise increases TCA intermediate concentrations during low‐calorie diet independent of insulin resistance among women with obesity
Tricarboxylic acid cycle intermediates (TCAi) have been proposed to act as myokines that influence energy metabolism. We determined if 2‐weeks of low‐calorie diet with interval exercise (LCD + INT) would increase TCAi more than a low‐calorie diet (LCD). Twenty‐three women were randomized to 2‐weeks...
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| Published in: | Physiological reports 2024-04, Vol.12 (7), p.e15987-n/a |
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| creator | Ragland, Tristan J. Malin, Steven K. |
| description | Tricarboxylic acid cycle intermediates (TCAi) have been proposed to act as myokines that influence energy metabolism. We determined if 2‐weeks of low‐calorie diet with interval exercise (LCD + INT) would increase TCAi more than a low‐calorie diet (LCD). Twenty‐three women were randomized to 2‐weeks of LCD (n = 12, 48.4 ± 2.5 years, 37.8 ± 1.5 kg/m2, ~1200 kcal/d) or LCD + INT (n = 11, 47.6 ± 4.3 years, 37.9 ± 2.3 kg/m2; 60 min/d supervised INT of 3 min 90% & 50% HRpeak). TCAi and amino acids (AA) were measured at 0 min of a 75 g OGTT, while glucose, insulin, and FFA were obtained at 0, 30, 60, 90, 120, and 180 min to assess total area under the curve (tAUC180min) and insulin resistance (IR; tAUC180min of Glucose × Insulin). Fuel use (indirect calorimetry) was also collected at 0, 60, 120, and 180 min as was fitness (VO2peak) and body composition (BodPod). Treatments reduced weight (p |
| doi_str_mv | 10.14814/phy2.15987 |
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We determined if 2‐weeks of low‐calorie diet with interval exercise (LCD + INT) would increase TCAi more than a low‐calorie diet (LCD). Twenty‐three women were randomized to 2‐weeks of LCD (n = 12, 48.4 ± 2.5 years, 37.8 ± 1.5 kg/m2, ~1200 kcal/d) or LCD + INT (n = 11, 47.6 ± 4.3 years, 37.9 ± 2.3 kg/m2; 60 min/d supervised INT of 3 min 90% & 50% HRpeak). TCAi and amino acids (AA) were measured at 0 min of a 75 g OGTT, while glucose, insulin, and FFA were obtained at 0, 30, 60, 90, 120, and 180 min to assess total area under the curve (tAUC180min) and insulin resistance (IR; tAUC180min of Glucose × Insulin). Fuel use (indirect calorimetry) was also collected at 0, 60, 120, and 180 min as was fitness (VO2peak) and body composition (BodPod). Treatments reduced weight (p < 0.001), fasting RER (p = 0.01), and IR (p = 0.03), although LCD + INT increased VO2peak (p = 0.02) and maintained RER tAUC180min (p = 0.05) versus LCD. Treatments increased FFA tAUC180min (p = 0.005), cis‐aconitate, isocitrate, and succinate (p ≤ 0.02), as well as reduced phenylalanine and tryptophan, cysteine (p ≤ 0.005). However, LCD + INT increased malate, citrate, α‐ketoglutarate, and alanine more than LCD (p ≤ 0.04). Thus, INT enhanced LCD effects on some TCAi in women with obesity independent of IR.</description><identifier>EISSN: 2051-817X</identifier><identifier>DOI: 10.14814/phy2.15987</identifier><identifier>PMID: 38561248</identifier><language>eng</language><publisher>United States: John Wiley and Sons Inc</publisher><subject>amino acids ; Caloric Restriction ; diabetes ; Female ; Glucose - metabolism ; Humans ; Insulin ; Insulin Resistance ; interval training ; obesity ; Obesity - metabolism ; Original ; tricarboxylic acid cycle</subject><ispartof>Physiological reports, 2024-04, Vol.12 (7), p.e15987-n/a</ispartof><rights>2024 The Authors. published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.</rights><rights>2024 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c5167-80aab104d11d37fd37252f14606309b0b6cb49f764a4ea692d8e996ecf7f4cc33</cites><orcidid>0000-0002-7360-6711</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10984826/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10984826/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,11541,27901,27902,36990,46027,46451,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38561248$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ragland, Tristan J.</creatorcontrib><creatorcontrib>Malin, Steven K.</creatorcontrib><title>Exercise increases TCA intermediate concentrations during low‐calorie diet independent of insulin resistance among women with obesity</title><title>Physiological reports</title><addtitle>Physiol Rep</addtitle><description>Tricarboxylic acid cycle intermediates (TCAi) have been proposed to act as myokines that influence energy metabolism. We determined if 2‐weeks of low‐calorie diet with interval exercise (LCD + INT) would increase TCAi more than a low‐calorie diet (LCD). Twenty‐three women were randomized to 2‐weeks of LCD (n = 12, 48.4 ± 2.5 years, 37.8 ± 1.5 kg/m2, ~1200 kcal/d) or LCD + INT (n = 11, 47.6 ± 4.3 years, 37.9 ± 2.3 kg/m2; 60 min/d supervised INT of 3 min 90% & 50% HRpeak). TCAi and amino acids (AA) were measured at 0 min of a 75 g OGTT, while glucose, insulin, and FFA were obtained at 0, 30, 60, 90, 120, and 180 min to assess total area under the curve (tAUC180min) and insulin resistance (IR; tAUC180min of Glucose × Insulin). Fuel use (indirect calorimetry) was also collected at 0, 60, 120, and 180 min as was fitness (VO2peak) and body composition (BodPod). Treatments reduced weight (p < 0.001), fasting RER (p = 0.01), and IR (p = 0.03), although LCD + INT increased VO2peak (p = 0.02) and maintained RER tAUC180min (p = 0.05) versus LCD. Treatments increased FFA tAUC180min (p = 0.005), cis‐aconitate, isocitrate, and succinate (p ≤ 0.02), as well as reduced phenylalanine and tryptophan, cysteine (p ≤ 0.005). However, LCD + INT increased malate, citrate, α‐ketoglutarate, and alanine more than LCD (p ≤ 0.04). Thus, INT enhanced LCD effects on some TCAi in women with obesity independent of IR.</description><subject>amino acids</subject><subject>Caloric Restriction</subject><subject>diabetes</subject><subject>Female</subject><subject>Glucose - metabolism</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin Resistance</subject><subject>interval training</subject><subject>obesity</subject><subject>Obesity - metabolism</subject><subject>Original</subject><subject>tricarboxylic acid cycle</subject><issn>2051-817X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>DOA</sourceid><recordid>eNp9kT1vFDEQhldIiEQhFT1yiYQu-Gu96wpFp0AiRYIiSFBZ_pi9c7RnH7Y3x3V0tPxGfgnmNkSkoRiPxvPOY2vepnlB8BnhPeFvtus9PSOt7LsnzTHFLVn0pPt81JzmfIsxJpgxifmz5oj1rSCU98fNj4tvkKzPgHywCXSGjG6W57UqkDbgvC6AbAwWQkm6-BgyclPyYYXGuPv1_afVY0wekPNQ6pSDLdQjFBSHWuZp9AElyD4XXSFIb2Id3cUNBLTzZY2iqc2yf948HfSY4fQ-nzSf3l3cLC8X1x_eXy3Prxe2JaJb9FhrQzB3hDjWDTVoSwfCBRYMS4ONsIbLoRNcc9BCUteDlALs0A3cWsZOmquZ66K-VdvkNzrtVdReHS5iWimdircjKE6pk2Dc0HHBsZG6M5y3lFPstKEtr6y3M2s7mbqqeUXjI-jjTvBrtYp3imDZ856KSnh1T0jx6wS5qI3PFsZRB4hTVgwzQhhlklbp61lqU8w5wfDwDsHqYL_6Y7862F_VL__92oP2r_FVQGfBzo-w_x9Lfbz8Qmfqb1vlwWY</recordid><startdate>202404</startdate><enddate>202404</enddate><creator>Ragland, Tristan J.</creator><creator>Malin, Steven K.</creator><general>John Wiley and Sons Inc</general><general>Wiley</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-7360-6711</orcidid></search><sort><creationdate>202404</creationdate><title>Exercise increases TCA intermediate concentrations during low‐calorie diet independent of insulin resistance among women with obesity</title><author>Ragland, Tristan J. ; Malin, Steven K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5167-80aab104d11d37fd37252f14606309b0b6cb49f764a4ea692d8e996ecf7f4cc33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>amino acids</topic><topic>Caloric Restriction</topic><topic>diabetes</topic><topic>Female</topic><topic>Glucose - metabolism</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin Resistance</topic><topic>interval training</topic><topic>obesity</topic><topic>Obesity - metabolism</topic><topic>Original</topic><topic>tricarboxylic acid cycle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ragland, Tristan J.</creatorcontrib><creatorcontrib>Malin, Steven K.</creatorcontrib><collection>Wiley Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Physiological reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ragland, Tristan J.</au><au>Malin, Steven K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exercise increases TCA intermediate concentrations during low‐calorie diet independent of insulin resistance among women with obesity</atitle><jtitle>Physiological reports</jtitle><addtitle>Physiol Rep</addtitle><date>2024-04</date><risdate>2024</risdate><volume>12</volume><issue>7</issue><spage>e15987</spage><epage>n/a</epage><pages>e15987-n/a</pages><eissn>2051-817X</eissn><abstract>Tricarboxylic acid cycle intermediates (TCAi) have been proposed to act as myokines that influence energy metabolism. We determined if 2‐weeks of low‐calorie diet with interval exercise (LCD + INT) would increase TCAi more than a low‐calorie diet (LCD). Twenty‐three women were randomized to 2‐weeks of LCD (n = 12, 48.4 ± 2.5 years, 37.8 ± 1.5 kg/m2, ~1200 kcal/d) or LCD + INT (n = 11, 47.6 ± 4.3 years, 37.9 ± 2.3 kg/m2; 60 min/d supervised INT of 3 min 90% & 50% HRpeak). TCAi and amino acids (AA) were measured at 0 min of a 75 g OGTT, while glucose, insulin, and FFA were obtained at 0, 30, 60, 90, 120, and 180 min to assess total area under the curve (tAUC180min) and insulin resistance (IR; tAUC180min of Glucose × Insulin). Fuel use (indirect calorimetry) was also collected at 0, 60, 120, and 180 min as was fitness (VO2peak) and body composition (BodPod). Treatments reduced weight (p < 0.001), fasting RER (p = 0.01), and IR (p = 0.03), although LCD + INT increased VO2peak (p = 0.02) and maintained RER tAUC180min (p = 0.05) versus LCD. Treatments increased FFA tAUC180min (p = 0.005), cis‐aconitate, isocitrate, and succinate (p ≤ 0.02), as well as reduced phenylalanine and tryptophan, cysteine (p ≤ 0.005). However, LCD + INT increased malate, citrate, α‐ketoglutarate, and alanine more than LCD (p ≤ 0.04). Thus, INT enhanced LCD effects on some TCAi in women with obesity independent of IR.</abstract><cop>United States</cop><pub>John Wiley and Sons Inc</pub><pmid>38561248</pmid><doi>10.14814/phy2.15987</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-7360-6711</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | amino acids Caloric Restriction diabetes Female Glucose - metabolism Humans Insulin Insulin Resistance interval training obesity Obesity - metabolism Original tricarboxylic acid cycle |
| title | Exercise increases TCA intermediate concentrations during low‐calorie diet independent of insulin resistance among women with obesity |
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