Vitamin B6 improves blood parameters in rats fed a protein-deficient diet and subjected to moderate, long-term exercise

Vitamin B6 is necessary for many enzymatic pathways (glucose and lipid metabolism, DNA/RNA synthesis, or modulation of gene expression) and affects immune cell function and blood-forming processes. We hypothesised that supplementing a protein-deficient diet with vitamin B6 may reduce the negative im...

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Bibliographic Details
Published in:Central-European journal of immunology 2019, Vol.44 (1), p.23-32
Main Authors: Kalicki, Bolesław, Lewicka, Aneta, Jęderka, Krystyna, Leśniak, Monika, Marszałkowska-Jakubik, Justyna, Lewicki, Sławomir
Format: Article
Language:English
Subjects:
Alanine
Asparagine
Blood levels
blood parameters
Body mass
Dietary supplements
DNA biosynthesis
exercise
Experimental Immunology
Gene expression
Glucose metabolism
Hemoglobin
immunology
Leukocytes
Lipid metabolism
Malnutrition
Nutrient deficiency
protein deficiency
Proteins
rats
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Vitamin B6
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Summary:Vitamin B6 is necessary for many enzymatic pathways (glucose and lipid metabolism, DNA/RNA synthesis, or modulation of gene expression) and affects immune cell function and blood-forming processes. We hypothesised that supplementing a protein-deficient diet with vitamin B6 may reduce the negative impact of protein malnutrition. Here, we evaluated the effect of moderate, long-term exercise (ninety days) on selected blood parameters in rats fed a normal diet, a protein-deficient diet, or a protein-deficient diet supplemented with vitamin B6. Selected haematological, immunological, and biochemical parameters were examined. A protein-deficient diet lasting 90 days caused significant reduction in body mass, increased activity of aminotransferases (asparagine and alanine), an increased percentage of innate cells in the blood, and decreased haemoglobin concentration in the blood. Adding vitamin B6 significantly increased body and muscle mass, decreased liver parameters, and caused normalisation of haemoglobin concentration and the proportion of white blood cells in the blood. These results indicate that vitamin B6 supplementation significantly improves the health of protein-malnourished rats and paves the way for the development of novel anti-malnutrition therapies.
ISSN:1426-3912
1644-4124
DOI:10.5114/ceji.2019.83266