Survey of artemisinin production by diverse Artemisia species in northern Pakistan

Artemisinin is the current drug of choice for treatment of malaria and a number of other diseases. It is obtained from the annual herb, Artemisia annua and some microbial sources by genetic engineering. There is a great concern that the artemisinin production at current rate will not meet the increa...

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Bibliographic Details
Published in:Malaria journal 2010-11, Vol.9 (1), p.310-310, Article 310
Main Authors: Mannan, Abdul, Ahmed, Ibrar, Arshad, Waheed, Asim, Muhammad F, Qureshi, Rizwana A, Hussain, Izhar, Mirza, Bushra
Format: Article
Language:English
Subjects:
Agricultural production
Antimalarials
Antimalarials - analysis
Artemisia
Artemisia - chemistry
Artemisia annua
Artemisia dracunculus
Artemisia roxburghiana
Artemisinin
Artemisinins - analysis
Causes of
Chromatography, High Pressure Liquid
Dracunculus
Drug therapy
Flowers
Flowers - chemistry
Genetic engineering
Health aspects
High-performance liquid chromatography
HPLC
Human diseases
Humans
Leaves
Liquid chromatography
Malaria
Pakistan
Pharmaceutical industry
Plant Leaves - chemistry
Plant Roots - chemistry
Plant Stems - chemistry
Production processes
Roots
Species
Stems
Surveying
Surveys
Vector-borne diseases
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Summary:Artemisinin is the current drug of choice for treatment of malaria and a number of other diseases. It is obtained from the annual herb, Artemisia annua and some microbial sources by genetic engineering. There is a great concern that the artemisinin production at current rate will not meet the increasing demand by the pharmaceutical industry, so looking for additional sources is imperative. In current study, artemisinin concentration was analysed and compared in the flowers, leaves, roots and stems of Artemisia annua and 14 other Artemisia species including two varieties each for Artemisia roxburghiana and Artemisia dracunculus using high performance liquid chromatography (HPLC). The highest artemisinin concentration was detected in the leaves (0.44 ± 0.03%) and flowers (0.42 ± 0.03%) of A. annua, followed by the flowers (0.34 ± .02%) of A. bushriences and leaves (0.27 ± 0%) of A. dracunculus var dracunculus. The average concentration of artemisinin varied in the order of flowers > leaves > stems > roots. This study identifies twelve novel plant sources of artemisinin, which may be helpful for pharmaceutical production of artemisinin. This is the first report of quantitative comparison of artemisinin among a large number of Artemisia species.
ISSN:1475-2875
1475-2875
DOI:10.1186/1475-2875-9-310