Genomic epidemiology of Streptococcus agalactiae ST283 in Southeast Asia

Streptococcus agalactiae , also known as Lancefield Group B Streptococcus (GBS), is typically regarded as a neonatal pathogen; however, several studies have shown that the bacteria are capable of causing invasive diseases in non-pregnant adults as well. The majority of documented cases were from Sou...

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Published in:Scientific reports 2022-03, Vol.12 (1), p.4185-4185, Article 4185
Main Authors: Aiewsakun, Pakorn, Ruangchai, Wuthiwat, Thawornwattana, Yuttapong, Jaemsai, Bharkbhoom, Mahasirimongkol, Surakameth, Homkaew, Anchalee, Suksomchit, Paveesuda, Dubbs, Padungsri, Palittapongarnpim, Prasit
Format: Article
Language:English
Subjects:
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631/181/757
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Drug resistance
Epidemiology
Genotypes
Humanities and Social Sciences
multidisciplinary
Neonates
Phenotypes
Population dynamics
Science
Science (multidisciplinary)
Spatial analysis
Streptococcus agalactiae
Streptococcus infections
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Summary:Streptococcus agalactiae , also known as Lancefield Group B Streptococcus (GBS), is typically regarded as a neonatal pathogen; however, several studies have shown that the bacteria are capable of causing invasive diseases in non-pregnant adults as well. The majority of documented cases were from Southeast Asian countries, and the most common genotype found was ST283, which is also known to be able to infect fish. This study sequenced 12 GBS ST283 samples collected from adult patients in Thailand. Together with publicly available sequences, we performed temporo-spatial analysis and estimated population dynamics of the bacteria. Putative drug resistance genes were also identified and characterized, and the drug resistance phenotypes were validated experimentally. The results, together with historical records, draw a detailed picture of the past transmission history of GBS ST283 in Southeast Asia.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-08097-0