Potential of Hibiscus sabdariffa L. and Hibiscus Acid to Reverse Skin Aging

Hibiscus sabdariffa L. (HS) has a long history of edible and medicinal uses. In this study, the biological activities of the extracts, chromatographic fractions, and hibiscus acid obtained from HS were evaluated for their potential bioactivities. Their ability to promote extracellular matrix synthes...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-09, Vol.27 (18), p.6076
Main Authors: Wang, Duanyang, Nagata, Maki, Matsumoto, Masako, Amen, Yhiya, Wang, Dongmei, Shimizu, Kuniyoshi
Format: Article
Language:English
Subjects:
Adenosine triphosphate
Aging
anti-inflammatory
Anti-inflammatory agents
ATP
bioactive compound
Carbonyl compounds
Carbonyls
Collagen
Cytotoxicity
Ethanol
Extracellular matrix
Fibroblasts
Fractionation
Hibiscus sabdariffa
Hibiscus sabdariffa L
Hyaluronic acid
Hydrogen peroxide
Immunoassays
Inflammation
Metabolism
Nitric oxide
Oxidative stress
Proteins
Roselle
Skin
Skin care
skin fibroblasts
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Summary:Hibiscus sabdariffa L. (HS) has a long history of edible and medicinal uses. In this study, the biological activities of the extracts, chromatographic fractions, and hibiscus acid obtained from HS were evaluated for their potential bioactivities. Their ability to promote extracellular matrix synthesis in skin fibroblasts was evaluated by enzyme-linked immunosorbent assays. Their anti-inflammatory activity was evaluated in a nitric oxide (NO)–Griess inflammatory experiment. Furthermore, hibiscus acid was found to have a strong anti-oxidative stress effect through the establishment of an oxidative stress model induced by hydrogen peroxide. Several assays indicated that hibiscus acid treatment can effectively reduce extracellular adenosine triphosphate (ATP) secretion and carbonyl protein production, as well as maintain a high level of reduced/oxidized glutathione (GSH/GSSG) in skin cells, thus providing a possible mechanism by which hibiscus acid can counter antioxidative stress. The present study is the first to explore the reversing skin aging potential and the contributory component of HS.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27186076