CAR-T therapy in oral squamous cell carcinoma: Current innovations and future prospects

•CAR-T therapy offers a groundbreaking, personalized approach to treating Oral Squamous Cell Carcinoma (OSCC).•Genetically engineers T-cells to target OSCC cells, providing a novel, direct cancer attack method.•Identifies ErbB and MUC1 as key antigens, highlighting precise targeting for effective tr...

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Bibliographic Details
Published in:Oral oncology reports 2024-06, Vol.10, p.100267, Article 100267
Main Authors: Madar, Inamul Hasan, Vimal, S., Fathima, Shazia, Thangavelu, Lakshmi
Format: Article
Language:English
Subjects:
CART-T therapy
Oral oncology
Oral squamous cell carcinoma
Personalized treatment
Targeted therapy
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Summary:•CAR-T therapy offers a groundbreaking, personalized approach to treating Oral Squamous Cell Carcinoma (OSCC).•Genetically engineers T-cells to target OSCC cells, providing a novel, direct cancer attack method.•Identifies ErbB and MUC1 as key antigens, highlighting precise targeting for effective treatment.•Addresses challenges with strategies like combination therapies to enhance efficacy in OSCC's complex environment.•Despite limitations, ongoing research into CAR-T therapy shows promising future prospects for OSCC treatment.
ISSN:2772-9060
2772-9060
DOI:10.1016/j.oor.2024.100267