CAR-T therapy in oral squamous cell carcinoma: Current innovations and future prospects

•CAR-T therapy offers a groundbreaking, personalized approach to treating Oral Squamous Cell Carcinoma (OSCC).•Genetically engineers T-cells to target OSCC cells, providing a novel, direct cancer attack method.•Identifies ErbB and MUC1 as key antigens, highlighting precise targeting for effective tr...

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Published in:Oral oncology reports 2024-06, Vol.10, p.100267, Article 100267
Main Authors: Madar, Inamul Hasan, Vimal, S., Fathima, Shazia, Thangavelu, Lakshmi
Format: Article
Language:English
Subjects:
CART-T therapy
Oral oncology
Oral squamous cell carcinoma
Personalized treatment
Targeted therapy
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creator Madar, Inamul Hasan
Vimal, S.
Fathima, Shazia
Thangavelu, Lakshmi
description •CAR-T therapy offers a groundbreaking, personalized approach to treating Oral Squamous Cell Carcinoma (OSCC).•Genetically engineers T-cells to target OSCC cells, providing a novel, direct cancer attack method.•Identifies ErbB and MUC1 as key antigens, highlighting precise targeting for effective treatment.•Addresses challenges with strategies like combination therapies to enhance efficacy in OSCC's complex environment.•Despite limitations, ongoing research into CAR-T therapy shows promising future prospects for OSCC treatment.
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subjects CART-T therapy
Oral oncology
Oral squamous cell carcinoma
Personalized treatment
Targeted therapy
title CAR-T therapy in oral squamous cell carcinoma: Current innovations and future prospects
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