Alpha-Amylase Inhibition and Antioxidative Capacity of Some Antidiabetic Plants Used by the Traditional Healers in Southeastern Nigeria

Oxidative stress plays a significant role in the pathogenesis of metabolic syndrome including diabetes mellitus (DM). The inhibition of alpha-amylase is an important therapeutic target in the regulation of postprandial increase of blood glucose in diabetic patients. The present study investigated th...

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Bibliographic Details
Published in:TheScientificWorld 2017, Vol.2017 (2017), p.1-11
Main Authors: Coopoosamy, Roger M., Ohanyerem, Princemartins E., Ijeh, Ifeoma I., Oyedemi, Blessing O., Oyedemi, Sunday O., Aiyegoro, Olayinka A.
Format: Article
Language:English
Subjects:
Agriculture
alpha-Amylases - antagonists & inhibitors
Anacardium occidentale
Antioxidants
Antioxidants - isolation & purification
Antioxidants - pharmacology
Ceiba pentandra
Diabetes
Drugs
Enzymes
Flavonoids
Flowers & plants
Gene expression
Herbal medicine
Humans
Hyperglycemia
Hypoglycemic Agents - isolation & purification
Hypoglycemic Agents - pharmacology
Insulin resistance
Kinases
Local government
Metabolic disorders
Nigeria
Oxidative stress
Phenols
Phenols - isolation & purification
Phenols - pharmacology
Plant extracts
Plant Extracts - pharmacology
Plant mitochondria
Plant species
Plants, Medicinal - chemistry
Population
Strophanthus
Studies
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Summary:Oxidative stress plays a significant role in the pathogenesis of metabolic syndrome including diabetes mellitus (DM). The inhibition of alpha-amylase is an important therapeutic target in the regulation of postprandial increase of blood glucose in diabetic patients. The present study investigated the alpha-amylase inhibitory and antioxidant potential of selected herbal drugs used in the treatment of DM by the traditional healers in Isiala Mbano and Ikwuano regions of southeastern Nigeria. Antioxidant activity was evaluated in terms of free radical scavenging, reducing power, and total phenolic (TPC) and flavonoid content (TFC) in consonance with the TLC profiling. The results showed that methanol crude extracts from Anacardium occidentale (AO) and Ceiba pentandra (CP) recorded higher TPC and TFC, potent free radical scavenging, and efficient reducing power (RP) as compared with other plant samples. All the plant extracts exhibited a relative alpha-amylase inhibition apart from Strophanthus hispidus (SH) extract with a negative effect. We discovered a mild to weak correlation between alpha-amylase inhibition or antioxidative capacity and the total phenol or flavonoid content. At least in part, the results obtained in this work support the traditional use of certain plant species in the treatment of patients with DM.
ISSN:2356-6140
1537-744X
DOI:10.1155/2017/3592491