Poor prognosis of NSCLC located in lower lobe is partly mediated by lower frequency of EGFR mutations

• Published in: Scientific reports 2020-09, Vol.10 (1), p.14933-14933, Article 14933
• Main Authors: Lee, Hyun Woo, Park, Young Sik, Park, Sangshin, Lee, Chang-Hoon
• Format: Article
• Language: English
• Subjects: 692/308/409; 692/420/2489/68/2486; Adenocarcinoma of Lung - genetics; Adenocarcinoma of Lung - pathology; Adenocarcinoma of Lung - surgery; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor - genetics; Breast cancer; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Non-Small-Cell Lung - surgery; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - surgery; Disease; ErbB Receptors - genetics; Female; Follow-Up Studies; Gelatinase B; Gene Expression Regulation, Neoplastic; Genes; Health risks; Histology; Humanities and Social Sciences; Humans; Lung cancer; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Lung Neoplasms - surgery; Male; Metastases; Metastasis; Middle Aged; Mortality risk; multidisciplinary; Mutation; Mutation Rate; Prognosis; Retrospective Studies; Science; Science (multidisciplinary); Sensitivity analysis; Survival Rate
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-71996-7

It is controversial whether a tumor located in the lower lobe is related with worse outcome of non-small cell lung cancer (NSCLC). This study aimed to clarify the prognostic role of primary tumor location in NSCLC. Patients newly diagnosed with NSCLC in a tertiary referral hospital from January 2011 to December 2014 were followed up for 5 years. Of the 2,289 NSCLC cases, 911 (39.8%) cases pertained to lower lobe cancers. Patients with lower lobe cancer showed a higher all-cause mortality rate than those with non-lower lobe cancer (48.6% vs. 40.3%, p