Association between number of dissected lymph nodes and survival in patients undergoing resection for clinical stage IA pure solid lung adenocarcinoma: a retrospective analysis

Background Lymph node dissection is essential for staging of pure solid lung adenocarcinoma and selection of treatment after surgical resection, particularly for stage I disease since the rate of lymph node metastasis can vary from 0 to 23.7%. Methods We retrospectively screened all adult patients (...

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Bibliographic Details
Published in:BMC pulmonary medicine 2023-10, Vol.23 (1), p.1-401, Article 401
Main Authors: Rong, Yu, Liu, Junfeng, Han, Nianqiao, Shi, Zhihua, Jiang, Tao, Zhang, Nan, Xu, Xi'e, Yin, Jinhuan, Du, Hui
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma of the lung
Antigens
Care and treatment
Development and progression
Diagnosis
Dissection
Family medical history
Health aspects
Lung cancer
Lymph node dissection
Lymph nodes
Lymphatic metastasis
Lymphatic system
Metastases
Metastasis
Neoplasm staging
Normal distribution
Patient outcomes
Patients
Pulmonology
Recurrence-free survival
Surgery
Survival
Thoracic surgery
Tumor staging
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Summary:Background Lymph node dissection is essential for staging of pure solid lung adenocarcinoma and selection of treatment after surgical resection, particularly for stage I disease since the rate of lymph node metastasis can vary from 0 to 23.7%. Methods We retrospectively screened all adult patients (18 years of age or older) who underwent lobectomy for pure solid cT1N0M0 lung adenocarcinoma between January 2015 and December 2017 at our center. Cox proportional hazard regression was used to assess the association between the number of dissected lymph nodes and recurrence-free survival (RFS) and to determine the optimal number of dissected lymph nodes. Results The final analysis included 458 patients (age: 60.26 [+ or -] 8.07 years; 241 women). RFS increased linearly with an increasing number of dissected lymph nodes at a range between 0 and 9. Kaplan-Meier analysis revealed significantly longer RFS in patients with [greater than or equal to] 9 vs.
ISSN:1471-2466
1471-2466
DOI:10.1186/s12890-023-02675-2