Investigating Post-translational Modifications in Neuropsychiatric Disease: The Next Frontier in Human Post-mortem Brain Research

Gene expression and translation have been extensively studied in human post-mortem brain tissue from subjects with psychiatric disease. Post-translational modifications (PTMs) have received less attention despite their implication by unbiased genetic studies and importance in regulating neuronal and...

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Bibliographic Details
Published in:Frontiers in molecular neuroscience 2021-07, Vol.14, p.689495-689495
Main Authors: Grubisha, Melanie J, Sweet, Robert A, MacDonald, Matthew L
Format: Article
Language:English
Subjects:
Alzheimer's disease
Autism
Bipolar disorder
Brain research
Consortia
Etiology
Gene expression
Genomics
Health risk assessment
Kinases
Mass spectrometry
Mass spectroscopy
Mental disorders
Neuroscience
Pathology
Phosphatase
post-mortem brain
Post-translation
post-translational modification
Proteins
proteomics
psychiatric disease
Schizophrenia
Scientific imaging
Working groups
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Summary:Gene expression and translation have been extensively studied in human post-mortem brain tissue from subjects with psychiatric disease. Post-translational modifications (PTMs) have received less attention despite their implication by unbiased genetic studies and importance in regulating neuronal and circuit function. Here we review the rationale for studying PTMs in psychiatric disease, recent findings in human post-mortem tissue, the required controls for these types of studies, and highlight the emerging mass spectrometry approaches transforming this research direction.
ISSN:1662-5099
1662-5099
DOI:10.3389/fnmol.2021.689495