Stability of Ampicillin plus Ceftriaxone Combined in Elastomeric Infusion Devices for Outpatient Parenteral Antimicrobial Therapy

Currently, ampicillin plus ceftriaxone (AC) is one of the preferred treatments for infective endocarditis. However, there is a lack of stability data for the combination of both drugs in elastomeric devices, so the inclusion of AC in Outpatient Parenteral Antimicrobial Therapy (OPAT) programs is cha...

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Published in:Antibiotics (Basel) 2023-02, Vol.12 (3), p.432
Main Authors: Fernández-Rubio, Beatriz, Herrera-Hidalgo, Laura, Luque-Márquez, Rafael, de Alarcón, Arístides, López-Cortés, Luis E, Luque-Pardos, Sonia, Gutiérrez-Urbón, José María, Fernández-Polo, Aurora, Gil-Navarro, María V, Gutiérrez-Valencia, Alicia
Format: Article
Language:English
Subjects:
Ampicillin
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Care and treatment
Ceftriaxone
Ceftriaxone sodium
Chromatography
Cost control
Elastomers
Endocarditis
Infections
Infective endocarditis
Mass spectrometry
outpatient parenteral antimicrobial therapy
Patient satisfaction
Scientific imaging
Sodium
Sodium chloride
stability
Stability analysis
Stability criteria
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Summary:Currently, ampicillin plus ceftriaxone (AC) is one of the preferred treatments for infective endocarditis. However, there is a lack of stability data for the combination of both drugs in elastomeric devices, so the inclusion of AC in Outpatient Parenteral Antimicrobial Therapy (OPAT) programs is challenging. The objective of the study was to determine the stability of AC in elastomeric pumps when stored at 8 ± 2 °C, 25 ± 2 °C, 30 ± 2 °C and 37 ± 2 °C using LC-MS/MS. The combination was diluted in 0.9% sodium chloride and the final concentrations were ampicillin 24 g/L plus ceftriaxone 8 g/L. Physical and chemical stability were evaluated at 12, 20, 24, 36 and 48 h after preparation. Stability was met at each time point if the percentage of intact drug was ≥90% of its respective baseline concentration and color and clearness remained unchanged. The drug combination was stable for 48 h when it was kept at 8 ± 2 °C. At 25 ± 2 °C and 30 ± 2 °C, they were stable for 24 h of storage. At 37 ± 2 °C, the stability criterion was not met at any time point. These results prove that AC could be included in OPAT programs using elastomeric infusion devices for the treatment of infections.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics12030432