Liraglutide improves adipose tissue remodeling and mitochondrial dynamics in a visceral obesity model induced by a high-fat diet

Central obesity is characterized by visceral adipose tissue (VAT) expansion, considered one of the main risk factors for metabolic complications. In recent years, new drugs have been studied for obesity treatment. Liraglutide (LGT), a GLP-1 agonist, decreases body weight, however, several mechanisms...

Full description

Saved in:
Bibliographic Details
Published in:Current research in pharmacology and drug discovery 2024-01, Vol.6, p.100185, Article 100185
Main Authors: Touceda, Vanessa, Fontana Estevez, Florencia, Cacciagiú, Leonardo, Finocchietto, Paola, Bustos, Romina, Vidal, Agustina, Berg, Gabriela, Morales, Celina, González, Germán E., Miksztowicz, Veronica
Format: Article
Language:English
Subjects:
Liraglutide
Metalloproteinase
Vascular density
Visceral adipose tissue
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c3945-abd06cb94fcea527ba8da9fa28339bcc7f200703b1966b38b623dc0cdc1b68f33
container_end_page
container_issue
container_start_page 100185
container_title Current research in pharmacology and drug discovery
container_volume 6
creator Touceda, Vanessa
Fontana Estevez, Florencia
Cacciagiú, Leonardo
Finocchietto, Paola
Bustos, Romina
Vidal, Agustina
Berg, Gabriela
Morales, Celina
González, Germán E.
Miksztowicz, Veronica
description Central obesity is characterized by visceral adipose tissue (VAT) expansion, considered one of the main risk factors for metabolic complications. In recent years, new drugs have been studied for obesity treatment. Liraglutide (LGT), a GLP-1 agonist, decreases body weight, however, several mechanisms of action on VAT are still unknown. to study the effect of LGT on factors associated with VAT remodeling and mitochondrial dynamics in mice fed a high-fat diet (HFD). C57BL/6 mice were divided into Control (C) and HFD. After 15 weeks of feeding, each group was subdivided according to LGT administration for 5 weeks: C, C + LGT, HFD, and HFD + LGT. In epididymal AT (EAT) we evaluated histological and mitochondrial characteristics, vascularity, gelatinase activity (MMPs), and galectin-3 expression. HFD presented larger adipocytes (p 
doi_str_mv 10.1016/j.crphar.2024.100185
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_42adaa588215451c84a3c3046776f537</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S2590257124000129</els_id><doaj_id>oai_doaj_org_article_42adaa588215451c84a3c3046776f537</doaj_id><sourcerecordid>3065984936</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3945-abd06cb94fcea527ba8da9fa28339bcc7f200703b1966b38b623dc0cdc1b68f33</originalsourceid><addsrcrecordid>eNp9Uk1vEzEUXCEQrUr_AUI-cknq77UvIFQBrRSJC5yt549NHO2ug70bKTd-Ok63VO2Fk633ZubZ86Zp3hO8JpjIm_3a5cMO8ppiymsJEyVeNZdUaLyioiWvn90vmutS9hhj2mqOpXrbXDCluMRYXzZ_NjHDtp-n6AOKwyGnYygIfDykEtAUS5kDymFIPvRx3CIYPRrilNwujT5H6JE_jTBEV1AcEaBjLC7kWk42lDid0AOz9vzsgkf2VDG7uN2tOpiQj2F617zpoC_h-vG8an59-_rz9m61-fH9_vbLZuWY5mIF1mPprOadCyBoa0F50B1QxZi2zrUdxbjFzBItpWXKSsq8w847YqXqGLtq7hddn2BvDjkOkE8mQTQPhZS3BvIUXR8Mp-ABhFKUCC6IUxyYY5jLtpWdYG3V-rxoHWY7BO_CONUvvxB92RnjzmzT0RBCRPVeV4WPjwo5_Z5DmcxwNq7vYQxpLoZhKbTimskK5QvU5VRKDt3THILNOQxmb5YwmHMYzBKGSvvw_I1PpH-rr4BPCyBU148xZFNcDGPdUszBTdWW-P8JfwEn8soI</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3065984936</pqid></control><display><type>article</type><title>Liraglutide improves adipose tissue remodeling and mitochondrial dynamics in a visceral obesity model induced by a high-fat diet</title><source>PubMed Central Free</source><source>ScienceDirect (Elsevier)</source><creator>Touceda, Vanessa ; Fontana Estevez, Florencia ; Cacciagiú, Leonardo ; Finocchietto, Paola ; Bustos, Romina ; Vidal, Agustina ; Berg, Gabriela ; Morales, Celina ; González, Germán E. ; Miksztowicz, Veronica</creator><creatorcontrib>Touceda, Vanessa ; Fontana Estevez, Florencia ; Cacciagiú, Leonardo ; Finocchietto, Paola ; Bustos, Romina ; Vidal, Agustina ; Berg, Gabriela ; Morales, Celina ; González, Germán E. ; Miksztowicz, Veronica</creatorcontrib><description><![CDATA[Central obesity is characterized by visceral adipose tissue (VAT) expansion, considered one of the main risk factors for metabolic complications. In recent years, new drugs have been studied for obesity treatment. Liraglutide (LGT), a GLP-1 agonist, decreases body weight, however, several mechanisms of action on VAT are still unknown. to study the effect of LGT on factors associated with VAT remodeling and mitochondrial dynamics in mice fed a high-fat diet (HFD). C57BL/6 mice were divided into Control (C) and HFD. After 15 weeks of feeding, each group was subdivided according to LGT administration for 5 weeks: C, C + LGT, HFD, and HFD + LGT. In epididymal AT (EAT) we evaluated histological and mitochondrial characteristics, vascularity, gelatinase activity (MMPs), and galectin-3 expression. HFD presented larger adipocytes (p < 0.05), and lower vascular density and MMP-9 activity (p < 0.01) than C, while a major number of smaller adipocytes (p < 0.05) and an increase in vascularity (p < 0.001) and MMP-9 activity (p < 0.01) was observed in HFD + LGT. Collagen content was higher (p < 0.05) in EAT from HFD and decreased in HFD + LGT. In C, C + LGT, and HFD + LGT, mitochondria were predominantly tubular-shaped while in HFD mitochondria were mostly spherical (p < 0.001). LGT positively influences VAT behavior by modulating gelatinase activity, enhancing vascularization, and improving adipocyte histological characteristics. Additionally, LGT improves mitochondrial dynamics, a process that would favor VAT functionality. [Display omitted] •Liraglutide improves histological characteristics of expanded adipose tissue.•An increase in vascularity and gelatinase activity was produced by liraglutide.•Collagen interstitial content decreases with liraglutide in visceral obesity.•Liraglutide promotes an increase in tubular-shaped mitochondria.]]></description><identifier>ISSN: 2590-2571</identifier><identifier>EISSN: 2590-2571</identifier><identifier>DOI: 10.1016/j.crphar.2024.100185</identifier><identifier>PMID: 38846009</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Liraglutide ; Metalloproteinase ; Vascular density ; Visceral adipose tissue</subject><ispartof>Current research in pharmacology and drug discovery, 2024-01, Vol.6, p.100185, Article 100185</ispartof><rights>2024 The Authors</rights><rights>2024 The Authors.</rights><rights>2024 The Authors 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3945-abd06cb94fcea527ba8da9fa28339bcc7f200703b1966b38b623dc0cdc1b68f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11153889/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S2590257124000129$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,3549,27924,27925,45780,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38846009$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Touceda, Vanessa</creatorcontrib><creatorcontrib>Fontana Estevez, Florencia</creatorcontrib><creatorcontrib>Cacciagiú, Leonardo</creatorcontrib><creatorcontrib>Finocchietto, Paola</creatorcontrib><creatorcontrib>Bustos, Romina</creatorcontrib><creatorcontrib>Vidal, Agustina</creatorcontrib><creatorcontrib>Berg, Gabriela</creatorcontrib><creatorcontrib>Morales, Celina</creatorcontrib><creatorcontrib>González, Germán E.</creatorcontrib><creatorcontrib>Miksztowicz, Veronica</creatorcontrib><title>Liraglutide improves adipose tissue remodeling and mitochondrial dynamics in a visceral obesity model induced by a high-fat diet</title><title>Current research in pharmacology and drug discovery</title><addtitle>Curr Res Pharmacol Drug Discov</addtitle><description><![CDATA[Central obesity is characterized by visceral adipose tissue (VAT) expansion, considered one of the main risk factors for metabolic complications. In recent years, new drugs have been studied for obesity treatment. Liraglutide (LGT), a GLP-1 agonist, decreases body weight, however, several mechanisms of action on VAT are still unknown. to study the effect of LGT on factors associated with VAT remodeling and mitochondrial dynamics in mice fed a high-fat diet (HFD). C57BL/6 mice were divided into Control (C) and HFD. After 15 weeks of feeding, each group was subdivided according to LGT administration for 5 weeks: C, C + LGT, HFD, and HFD + LGT. In epididymal AT (EAT) we evaluated histological and mitochondrial characteristics, vascularity, gelatinase activity (MMPs), and galectin-3 expression. HFD presented larger adipocytes (p < 0.05), and lower vascular density and MMP-9 activity (p < 0.01) than C, while a major number of smaller adipocytes (p < 0.05) and an increase in vascularity (p < 0.001) and MMP-9 activity (p < 0.01) was observed in HFD + LGT. Collagen content was higher (p < 0.05) in EAT from HFD and decreased in HFD + LGT. In C, C + LGT, and HFD + LGT, mitochondria were predominantly tubular-shaped while in HFD mitochondria were mostly spherical (p < 0.001). LGT positively influences VAT behavior by modulating gelatinase activity, enhancing vascularization, and improving adipocyte histological characteristics. Additionally, LGT improves mitochondrial dynamics, a process that would favor VAT functionality. [Display omitted] •Liraglutide improves histological characteristics of expanded adipose tissue.•An increase in vascularity and gelatinase activity was produced by liraglutide.•Collagen interstitial content decreases with liraglutide in visceral obesity.•Liraglutide promotes an increase in tubular-shaped mitochondria.]]></description><subject>Liraglutide</subject><subject>Metalloproteinase</subject><subject>Vascular density</subject><subject>Visceral adipose tissue</subject><issn>2590-2571</issn><issn>2590-2571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp9Uk1vEzEUXCEQrUr_AUI-cknq77UvIFQBrRSJC5yt549NHO2ug70bKTd-Ok63VO2Fk633ZubZ86Zp3hO8JpjIm_3a5cMO8ppiymsJEyVeNZdUaLyioiWvn90vmutS9hhj2mqOpXrbXDCluMRYXzZ_NjHDtp-n6AOKwyGnYygIfDykEtAUS5kDymFIPvRx3CIYPRrilNwujT5H6JE_jTBEV1AcEaBjLC7kWk42lDid0AOz9vzsgkf2VDG7uN2tOpiQj2F617zpoC_h-vG8an59-_rz9m61-fH9_vbLZuWY5mIF1mPprOadCyBoa0F50B1QxZi2zrUdxbjFzBItpWXKSsq8w847YqXqGLtq7hddn2BvDjkOkE8mQTQPhZS3BvIUXR8Mp-ABhFKUCC6IUxyYY5jLtpWdYG3V-rxoHWY7BO_CONUvvxB92RnjzmzT0RBCRPVeV4WPjwo5_Z5DmcxwNq7vYQxpLoZhKbTimskK5QvU5VRKDt3THILNOQxmb5YwmHMYzBKGSvvw_I1PpH-rr4BPCyBU148xZFNcDGPdUszBTdWW-P8JfwEn8soI</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Touceda, Vanessa</creator><creator>Fontana Estevez, Florencia</creator><creator>Cacciagiú, Leonardo</creator><creator>Finocchietto, Paola</creator><creator>Bustos, Romina</creator><creator>Vidal, Agustina</creator><creator>Berg, Gabriela</creator><creator>Morales, Celina</creator><creator>González, Germán E.</creator><creator>Miksztowicz, Veronica</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20240101</creationdate><title>Liraglutide improves adipose tissue remodeling and mitochondrial dynamics in a visceral obesity model induced by a high-fat diet</title><author>Touceda, Vanessa ; Fontana Estevez, Florencia ; Cacciagiú, Leonardo ; Finocchietto, Paola ; Bustos, Romina ; Vidal, Agustina ; Berg, Gabriela ; Morales, Celina ; González, Germán E. ; Miksztowicz, Veronica</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3945-abd06cb94fcea527ba8da9fa28339bcc7f200703b1966b38b623dc0cdc1b68f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Liraglutide</topic><topic>Metalloproteinase</topic><topic>Vascular density</topic><topic>Visceral adipose tissue</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Touceda, Vanessa</creatorcontrib><creatorcontrib>Fontana Estevez, Florencia</creatorcontrib><creatorcontrib>Cacciagiú, Leonardo</creatorcontrib><creatorcontrib>Finocchietto, Paola</creatorcontrib><creatorcontrib>Bustos, Romina</creatorcontrib><creatorcontrib>Vidal, Agustina</creatorcontrib><creatorcontrib>Berg, Gabriela</creatorcontrib><creatorcontrib>Morales, Celina</creatorcontrib><creatorcontrib>González, Germán E.</creatorcontrib><creatorcontrib>Miksztowicz, Veronica</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Current research in pharmacology and drug discovery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Touceda, Vanessa</au><au>Fontana Estevez, Florencia</au><au>Cacciagiú, Leonardo</au><au>Finocchietto, Paola</au><au>Bustos, Romina</au><au>Vidal, Agustina</au><au>Berg, Gabriela</au><au>Morales, Celina</au><au>González, Germán E.</au><au>Miksztowicz, Veronica</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Liraglutide improves adipose tissue remodeling and mitochondrial dynamics in a visceral obesity model induced by a high-fat diet</atitle><jtitle>Current research in pharmacology and drug discovery</jtitle><addtitle>Curr Res Pharmacol Drug Discov</addtitle><date>2024-01-01</date><risdate>2024</risdate><volume>6</volume><spage>100185</spage><pages>100185-</pages><artnum>100185</artnum><issn>2590-2571</issn><eissn>2590-2571</eissn><abstract><![CDATA[Central obesity is characterized by visceral adipose tissue (VAT) expansion, considered one of the main risk factors for metabolic complications. In recent years, new drugs have been studied for obesity treatment. Liraglutide (LGT), a GLP-1 agonist, decreases body weight, however, several mechanisms of action on VAT are still unknown. to study the effect of LGT on factors associated with VAT remodeling and mitochondrial dynamics in mice fed a high-fat diet (HFD). C57BL/6 mice were divided into Control (C) and HFD. After 15 weeks of feeding, each group was subdivided according to LGT administration for 5 weeks: C, C + LGT, HFD, and HFD + LGT. In epididymal AT (EAT) we evaluated histological and mitochondrial characteristics, vascularity, gelatinase activity (MMPs), and galectin-3 expression. HFD presented larger adipocytes (p < 0.05), and lower vascular density and MMP-9 activity (p < 0.01) than C, while a major number of smaller adipocytes (p < 0.05) and an increase in vascularity (p < 0.001) and MMP-9 activity (p < 0.01) was observed in HFD + LGT. Collagen content was higher (p < 0.05) in EAT from HFD and decreased in HFD + LGT. In C, C + LGT, and HFD + LGT, mitochondria were predominantly tubular-shaped while in HFD mitochondria were mostly spherical (p < 0.001). LGT positively influences VAT behavior by modulating gelatinase activity, enhancing vascularization, and improving adipocyte histological characteristics. Additionally, LGT improves mitochondrial dynamics, a process that would favor VAT functionality. [Display omitted] •Liraglutide improves histological characteristics of expanded adipose tissue.•An increase in vascularity and gelatinase activity was produced by liraglutide.•Collagen interstitial content decreases with liraglutide in visceral obesity.•Liraglutide promotes an increase in tubular-shaped mitochondria.]]></abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>38846009</pmid><doi>10.1016/j.crphar.2024.100185</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2590-2571
ispartof Current research in pharmacology and drug discovery, 2024-01, Vol.6, p.100185, Article 100185
issn 2590-2571
2590-2571
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_42adaa588215451c84a3c3046776f537
source PubMed Central Free; ScienceDirect (Elsevier)
subjects Liraglutide
Metalloproteinase
Vascular density
Visceral adipose tissue
title Liraglutide improves adipose tissue remodeling and mitochondrial dynamics in a visceral obesity model induced by a high-fat diet
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T20%3A35%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Liraglutide%20improves%20adipose%20tissue%20remodeling%20and%20mitochondrial%20dynamics%20in%20a%20visceral%20obesity%20model%20induced%20by%20a%20high-fat%20diet&rft.jtitle=Current%20research%20in%20pharmacology%20and%20drug%20discovery&rft.au=Touceda,%20Vanessa&rft.date=2024-01-01&rft.volume=6&rft.spage=100185&rft.pages=100185-&rft.artnum=100185&rft.issn=2590-2571&rft.eissn=2590-2571&rft_id=info:doi/10.1016/j.crphar.2024.100185&rft_dat=%3Cproquest_doaj_%3E3065984936%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3945-abd06cb94fcea527ba8da9fa28339bcc7f200703b1966b38b623dc0cdc1b68f33%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3065984936&rft_id=info:pmid/38846009&rfr_iscdi=true