Conjunctival Extramedullary Plasmacytoma in Dogs and a Cat: Clinical Characteristics and Histopathological Findings

Background: Extramedullary plasmacytoma (EMP) is a plasma cell tumor that is very rarely reported in ocular and adnexal tissue and is usually solitary and benign. Methods: This study evaluated seven cases from different ophthalmology referrals submitted for histopathological analysis between 2013 an...

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Published in:Animals (Basel) 2022-11, Vol.12 (21), p.3015
Main Authors: Rawicka, Aleksandra, Crasta, Manuela, Guandalini, Adolfo, Peruccio, Claudio, Multari, Domenico, Rondena, Marco, D’Anna, Nunzio, Giudice, Chiara
Format: Article
Language:English
Subjects:
Antibodies
Biopsy
Bone marrow
cat
Cloning
Conjunctiva
Cryotherapy
dog
extramedullary plasmacytoma
eye
Eyelid
Giant cells
Mitosis
Multiple myeloma
Nodules
Ophthalmology
Plasma cells
Plasmacytoma
Proteins
Salmon
Surgery
Tumors
Ultrasonic imaging
Urine
Veterinary medicine
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Summary:Background: Extramedullary plasmacytoma (EMP) is a plasma cell tumor that is very rarely reported in ocular and adnexal tissue and is usually solitary and benign. Methods: This study evaluated seven cases from different ophthalmology referrals submitted for histopathological analysis between 2013 and 2022. Results: EMPs were diagnosed in a 9-year-old domestic short-haired cat and in six dogs (median age, 10 years): three English Cocker Spaniels, a Golden Retriever, a Maltese, and a Pinscher. EMPs affected the third eyelid conjunctiva in five cases (5/7), followed by the superior bulbar (1/7) and palpebral conjunctivae (1/7), respectively, and were presented mostly as well-defined, salmon-colored nodules. Histopathologically, the masses were composed of sheets and packets of round cells morphologically consistent with mature plasma cells with mild anisocytosis and anisokaryosis; mitosis and binucleated giant cells were rarely observed. Follow up for 6/7 cases ranged from 6 months to 2 years. No signs of recurrence or systemic involvement (multiple myeloma) were observed. Conclusions: EMP should be included in the differential diagnoses of canine and feline conjunctival masses. Staging recommendations should include multiple myeloma diagnostic evaluation. Our results suggest that primary conjunctival EMP does not appear to be locally aggressive and has low systemic involvement behavior. The local surgical excision alone or combined with cryotherapy should be curative.
ISSN:2076-2615
2076-2615
DOI:10.3390/ani12213015