Measurement of myocardial native T1 in cardiovascular diseases and norm in 1291 subjects

• Published in: Journal of cardiovascular magnetic resonance 2017-09, Vol.19 (1), p.74-74, Article 74
• Main Authors: Liu, Joanna M, Liu, Alexander, Leal, Joana, McMillan, Fiona, Francis, Jane, Greiser, Andreas, Rider, Oliver J, Myerson, Saul, Neubauer, Stefan, Ferreira, Vanessa M, Piechnik, Stefan K
• Format: Article
• Language: English
• Subjects: Abnormalities; Adult; Affected myocardium; Aged; Cardiac magnetic resonance; Cardiomyopathy; Cardiovascular disease; Cardiovascular diseases; Care and treatment; Clinical trials; Diagnosis; Female; Gadolinium; Heart - anatomy & histology; Heart - diagnostic imaging; Heart attacks; Heart diseases; Heart Diseases - diagnostic imaging; Humans; Late gadolinium enhancement; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Mapping; Measurement; Methods; Middle Aged; Myocardium; Normality; Pathology; Patients; Reference myocardium; Reproducibility of Results; Septum; ShMOLLI; Studies; T1-Mapping; Values
• ISSN: 1097-6647; 1532-429X
• DOI: 10.1186/s12968-017-0386-y

Native T1-mapping provides quantitative myocardial tissue characterization for cardiovascular diseases (CVD), without the need for gadolinium. However, its translation into clinical practice is hindered by differences between techniques and the lack of established reference values. We provide typical myocardial T1-ranges for 18 commonly encountered CVDs using a single T1-mapping technique - Shortened Look-Locker Inversion Recovery (ShMOLLI), also used in the large UK Biobank and Hypertrophic Cardiomyopathy Registry study. We analyzed 1291 subjects who underwent CMR (1.5-Tesla, MAGNETOM-Avanto, Siemens Healthcare, Erlangen, Germany) between 2009 and 2016, who had a single CVD diagnosis, with mid-ventricular T1-map assessment. A region of interest (ROI) was placed on native T1-maps in the "most-affected myocardium", characterized by the presence of late gadolinium enhancement (LGE), or regional wall motion abnormalities (RWMA) on cines. Another ROI was placed in the "reference myocardium" as far as possible from LGE/RWMA, and in the septum if no focal abnormality was present. To further define normality, we included native T1 of healthy subjects from an existing dataset after sub-endocardial pixel-erosions. Native T1 of patients with normal CMR (938 ± 21 ms) was similar compared to healthy subjects (941 ± 23 ms). Across all patient groups (57 ± 19 yrs., 65% males), focally affected myocardium had significantly different T1 value compared to reference myocardium (all p