Measurement of myocardial native T1 in cardiovascular diseases and norm in 1291 subjects

Native T1-mapping provides quantitative myocardial tissue characterization for cardiovascular diseases (CVD), without the need for gadolinium. However, its translation into clinical practice is hindered by differences between techniques and the lack of established reference values. We provide typica...

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Published in:Journal of cardiovascular magnetic resonance 2017-09, Vol.19 (1), p.74-74, Article 74
Main Authors: Liu, Joanna M, Liu, Alexander, Leal, Joana, McMillan, Fiona, Francis, Jane, Greiser, Andreas, Rider, Oliver J, Myerson, Saul, Neubauer, Stefan, Ferreira, Vanessa M, Piechnik, Stefan K
Format: Article
Language:English
Subjects:
Abnormalities
Adult
Affected myocardium
Aged
Cardiac magnetic resonance
Cardiomyopathy
Cardiovascular disease
Cardiovascular diseases
Care and treatment
Clinical trials
Diagnosis
Female
Gadolinium
Heart - anatomy & histology
Heart - diagnostic imaging
Heart attacks
Heart diseases
Heart Diseases - diagnostic imaging
Humans
Late gadolinium enhancement
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Mapping
Measurement
Methods
Middle Aged
Myocardium
Normality
Pathology
Patients
Reference myocardium
Reproducibility of Results
Septum
ShMOLLI
Studies
T1-Mapping
Values
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cited_by cdi_FETCH-LOGICAL-c591t-a739cba33cdaa637c84838baea6c485c128de9fcd86ba62c5713b611795767b63
cites cdi_FETCH-LOGICAL-c591t-a739cba33cdaa637c84838baea6c485c128de9fcd86ba62c5713b611795767b63
container_end_page 74
container_issue 1
container_start_page 74
container_title Journal of cardiovascular magnetic resonance
container_volume 19
creator Liu, Joanna M
Liu, Alexander
Leal, Joana
McMillan, Fiona
Francis, Jane
Greiser, Andreas
Rider, Oliver J
Myerson, Saul
Neubauer, Stefan
Ferreira, Vanessa M
Piechnik, Stefan K
description Native T1-mapping provides quantitative myocardial tissue characterization for cardiovascular diseases (CVD), without the need for gadolinium. However, its translation into clinical practice is hindered by differences between techniques and the lack of established reference values. We provide typical myocardial T1-ranges for 18 commonly encountered CVDs using a single T1-mapping technique - Shortened Look-Locker Inversion Recovery (ShMOLLI), also used in the large UK Biobank and Hypertrophic Cardiomyopathy Registry study. We analyzed 1291 subjects who underwent CMR (1.5-Tesla, MAGNETOM-Avanto, Siemens Healthcare, Erlangen, Germany) between 2009 and 2016, who had a single CVD diagnosis, with mid-ventricular T1-map assessment. A region of interest (ROI) was placed on native T1-maps in the "most-affected myocardium", characterized by the presence of late gadolinium enhancement (LGE), or regional wall motion abnormalities (RWMA) on cines. Another ROI was placed in the "reference myocardium" as far as possible from LGE/RWMA, and in the septum if no focal abnormality was present. To further define normality, we included native T1 of healthy subjects from an existing dataset after sub-endocardial pixel-erosions. Native T1 of patients with normal CMR (938 ± 21 ms) was similar compared to healthy subjects (941 ± 23 ms). Across all patient groups (57 ± 19 yrs., 65% males), focally affected myocardium had significantly different T1 value compared to reference myocardium (all p 
doi_str_mv 10.1186/s12968-017-0386-y
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However, its translation into clinical practice is hindered by differences between techniques and the lack of established reference values. We provide typical myocardial T1-ranges for 18 commonly encountered CVDs using a single T1-mapping technique - Shortened Look-Locker Inversion Recovery (ShMOLLI), also used in the large UK Biobank and Hypertrophic Cardiomyopathy Registry study. We analyzed 1291 subjects who underwent CMR (1.5-Tesla, MAGNETOM-Avanto, Siemens Healthcare, Erlangen, Germany) between 2009 and 2016, who had a single CVD diagnosis, with mid-ventricular T1-map assessment. A region of interest (ROI) was placed on native T1-maps in the "most-affected myocardium", characterized by the presence of late gadolinium enhancement (LGE), or regional wall motion abnormalities (RWMA) on cines. Another ROI was placed in the "reference myocardium" as far as possible from LGE/RWMA, and in the septum if no focal abnormality was present. To further define normality, we included native T1 of healthy subjects from an existing dataset after sub-endocardial pixel-erosions. Native T1 of patients with normal CMR (938 ± 21 ms) was similar compared to healthy subjects (941 ± 23 ms). Across all patient groups (57 ± 19 yrs., 65% males), focally affected myocardium had significantly different T1 value compared to reference myocardium (all p &lt; 0.001). In the affected myocardium, cardiac amyloidosis (1119 ± 61 ms) had the highest native T1 compared to normal and all other CVDs, while iron-overload (795 ± 58 ms) and Anderson-Fabry disease (863 ± 23 ms) had the lowest native reference T1 (all p &lt; 0.001). Future studies designed to detect the large T1 differences between affected and reference myocardium are estimated to require small sample-sizes (n &lt; 50). However, studies designed to detect the small T1 differences between reference myocardium in CVDs and healthy controls can require several thousand of subjects. We provide typical T1-ranges for common clinical cardiac conditions in the largest cohort to-date, using ShMOLLI T1-mapping at 1.5 T. 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However, its translation into clinical practice is hindered by differences between techniques and the lack of established reference values. We provide typical myocardial T1-ranges for 18 commonly encountered CVDs using a single T1-mapping technique - Shortened Look-Locker Inversion Recovery (ShMOLLI), also used in the large UK Biobank and Hypertrophic Cardiomyopathy Registry study. We analyzed 1291 subjects who underwent CMR (1.5-Tesla, MAGNETOM-Avanto, Siemens Healthcare, Erlangen, Germany) between 2009 and 2016, who had a single CVD diagnosis, with mid-ventricular T1-map assessment. A region of interest (ROI) was placed on native T1-maps in the "most-affected myocardium", characterized by the presence of late gadolinium enhancement (LGE), or regional wall motion abnormalities (RWMA) on cines. Another ROI was placed in the "reference myocardium" as far as possible from LGE/RWMA, and in the septum if no focal abnormality was present. To further define normality, we included native T1 of healthy subjects from an existing dataset after sub-endocardial pixel-erosions. Native T1 of patients with normal CMR (938 ± 21 ms) was similar compared to healthy subjects (941 ± 23 ms). Across all patient groups (57 ± 19 yrs., 65% males), focally affected myocardium had significantly different T1 value compared to reference myocardium (all p &lt; 0.001). In the affected myocardium, cardiac amyloidosis (1119 ± 61 ms) had the highest native T1 compared to normal and all other CVDs, while iron-overload (795 ± 58 ms) and Anderson-Fabry disease (863 ± 23 ms) had the lowest native reference T1 (all p &lt; 0.001). Future studies designed to detect the large T1 differences between affected and reference myocardium are estimated to require small sample-sizes (n &lt; 50). However, studies designed to detect the small T1 differences between reference myocardium in CVDs and healthy controls can require several thousand of subjects. We provide typical T1-ranges for common clinical cardiac conditions in the largest cohort to-date, using ShMOLLI T1-mapping at 1.5 T. Sample-size calculations from this study may be useful for the design of future studies and trials that use T1-mapping as an endpoint.</description><subject>Abnormalities</subject><subject>Adult</subject><subject>Affected myocardium</subject><subject>Aged</subject><subject>Cardiac magnetic resonance</subject><subject>Cardiomyopathy</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Care and treatment</subject><subject>Clinical trials</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Gadolinium</subject><subject>Heart - anatomy &amp; histology</subject><subject>Heart - diagnostic imaging</subject><subject>Heart attacks</subject><subject>Heart diseases</subject><subject>Heart Diseases - diagnostic imaging</subject><subject>Humans</subject><subject>Late gadolinium enhancement</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Mapping</subject><subject>Measurement</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Myocardium</subject><subject>Normality</subject><subject>Pathology</subject><subject>Patients</subject><subject>Reference myocardium</subject><subject>Reproducibility of Results</subject><subject>Septum</subject><subject>ShMOLLI</subject><subject>Studies</subject><subject>T1-Mapping</subject><subject>Values</subject><issn>1097-6647</issn><issn>1532-429X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkk9r3DAQxU1padK0H6CXYiiEXpxqLOvfpRBC2wRSekkhNzGW5F0ttpVK9sJ--8rZJM2WooPE6PeeRsMrivdAzgAk_5ygVlxWBERFqOTV7kVxDIzWVVOr25f5TJSoOG_EUfEmpQ0hoAQRr4ujWirWcArHxe0Ph2mObnDjVIauHHbBYLQe-3LEyW9deQOlH8v7YthiMnOPsbQ-ZZ1LJY62HEMcFiZ3A2Wa240zU3pbvOqwT-7dw35S_Pr29ebisrr--f3q4vy6MkzBVKGgyrRIqbGInAojG0lliw65aSQzUEvrVGes5C3y2jABtOUAQjHBRcvpSXG197UBN_ou-gHjTgf0-r4Q4kpjnLzpnW7q1nXoCABjjeRc2o61jlgqOOES2-z1Ze91N7eDsybPJGJ_YHp4M_q1XoWtZhykqJts8OnBIIbfs0uTHnwyru9xdGFOGlTTNJQLWPr--A-6CXMc86gWiitJOKN_qRXmD_ixC_lds5jqc0aEIhQYZOrsP1Re1g3ehNF1PtcPBKfPBGuH_bROoZ8nH8Z0CMIeNDGkFF33NAwgesmg3mdQ5wzqJYN6lzUfnk_xSfEYOvoHvlLVIw</recordid><startdate>20170928</startdate><enddate>20170928</enddate><creator>Liu, Joanna M</creator><creator>Liu, Alexander</creator><creator>Leal, Joana</creator><creator>McMillan, Fiona</creator><creator>Francis, Jane</creator><creator>Greiser, Andreas</creator><creator>Rider, Oliver J</creator><creator>Myerson, Saul</creator><creator>Neubauer, Stefan</creator><creator>Ferreira, Vanessa M</creator><creator>Piechnik, Stefan K</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7SC</scope><scope>7SP</scope><scope>7U5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>JQ2</scope><scope>K9.</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>M7Z</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20170928</creationdate><title>Measurement of myocardial native T1 in cardiovascular diseases and norm in 1291 subjects</title><author>Liu, Joanna M ; 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However, its translation into clinical practice is hindered by differences between techniques and the lack of established reference values. We provide typical myocardial T1-ranges for 18 commonly encountered CVDs using a single T1-mapping technique - Shortened Look-Locker Inversion Recovery (ShMOLLI), also used in the large UK Biobank and Hypertrophic Cardiomyopathy Registry study. We analyzed 1291 subjects who underwent CMR (1.5-Tesla, MAGNETOM-Avanto, Siemens Healthcare, Erlangen, Germany) between 2009 and 2016, who had a single CVD diagnosis, with mid-ventricular T1-map assessment. A region of interest (ROI) was placed on native T1-maps in the "most-affected myocardium", characterized by the presence of late gadolinium enhancement (LGE), or regional wall motion abnormalities (RWMA) on cines. Another ROI was placed in the "reference myocardium" as far as possible from LGE/RWMA, and in the septum if no focal abnormality was present. To further define normality, we included native T1 of healthy subjects from an existing dataset after sub-endocardial pixel-erosions. Native T1 of patients with normal CMR (938 ± 21 ms) was similar compared to healthy subjects (941 ± 23 ms). Across all patient groups (57 ± 19 yrs., 65% males), focally affected myocardium had significantly different T1 value compared to reference myocardium (all p &lt; 0.001). In the affected myocardium, cardiac amyloidosis (1119 ± 61 ms) had the highest native T1 compared to normal and all other CVDs, while iron-overload (795 ± 58 ms) and Anderson-Fabry disease (863 ± 23 ms) had the lowest native reference T1 (all p &lt; 0.001). Future studies designed to detect the large T1 differences between affected and reference myocardium are estimated to require small sample-sizes (n &lt; 50). However, studies designed to detect the small T1 differences between reference myocardium in CVDs and healthy controls can require several thousand of subjects. We provide typical T1-ranges for common clinical cardiac conditions in the largest cohort to-date, using ShMOLLI T1-mapping at 1.5 T. Sample-size calculations from this study may be useful for the design of future studies and trials that use T1-mapping as an endpoint.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>28954631</pmid><doi>10.1186/s12968-017-0386-y</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
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ispartof Journal of cardiovascular magnetic resonance, 2017-09, Vol.19 (1), p.74-74, Article 74
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subjects Abnormalities
Adult
Affected myocardium
Aged
Cardiac magnetic resonance
Cardiomyopathy
Cardiovascular disease
Cardiovascular diseases
Care and treatment
Clinical trials
Diagnosis
Female
Gadolinium
Heart - anatomy & histology
Heart - diagnostic imaging
Heart attacks
Heart diseases
Heart Diseases - diagnostic imaging
Humans
Late gadolinium enhancement
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Mapping
Measurement
Methods
Middle Aged
Myocardium
Normality
Pathology
Patients
Reference myocardium
Reproducibility of Results
Septum
ShMOLLI
Studies
T1-Mapping
Values
title Measurement of myocardial native T1 in cardiovascular diseases and norm in 1291 subjects
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