Meperidine (pethidine) versus morphine in acute pain management of opioid-dependent patients

The present study aimed to evaluate the effectiveness of morphine and meperidine (pethidine) as pain relief in opioid-dependent patients with acute pain. A total of 122 opioid-dependent patients with acute pain were included in the study. Their pain severity was assessed, using visual analog scale (...

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Bibliographic Details
Published in:Open access emergency medicine 2016-01, Vol.8, p.57-59
Main Authors: Solhi, Hassan, Sanaei-Zadeh, Hossein, Solhi, Sadra, Azizi Nadian, Mohammad Ali, Gharibi, Morteza, Sadeghi Sedeh, Bahman
Format: Article
Language:English
Subjects:
Analgesics
Analysis
Care and treatment
Emergency medical care
Emergency medicine
Heroin
Medicine
Meperidine
Methadone
Morphine
Narcotics
Opioid dependency
Original Research
Pain
Pain management
Patients
Physiology
Standard deviation
Toxicology
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Summary:The present study aimed to evaluate the effectiveness of morphine and meperidine (pethidine) as pain relief in opioid-dependent patients with acute pain. A total of 122 opioid-dependent patients with acute pain were included in the study. Their pain severity was assessed, using visual analog scale (VAS) scores ranging from 0 to 10. The patients randomly received intravenous morphine (up to 0.15 mg/kg) or meperidine (up to 1.5 mg/kg) for pain control by patient control analgesia (PCA) pump. The clinical opioid withdrawal scale (COWS) was employed for the assessment of withdrawal symptoms. The pain relief and the emergence of withdrawal symptoms were measured at 15, 30, and 60 minutes after drug administration. The patients who received morphine reported a better pain control compared to those who received meperidine (mean ± standard deviation [SD] VAS scores 4.11±1.90 vs 5.85±2.08 at the end of the study; P
ISSN:1179-1500
1179-1500
DOI:10.2147/OAEM.S112803