Enamel hypoplasia in a litter of rats with alloxan-induced diabetes mellitus

Enamel hypoplasia is an important clinical problem commonly seen in children born to diabetic women. We aimed to characterize the enamel hypoplasia in Wistar rats born to alloxan-induced diabetes mellitus rats. Groups consisted of pregnant rats supplemented (ISDR) or not (NISDR) with insulin and con...

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Bibliographic Details
Published in:Brazilian dental journal 2003, Vol.14 (2), p.87-93
Main Authors: Silva-Sousa, Yara Teresinha Corrêa, Peres, Luiz Cesar, Foss, Milton Cesar
Format: Article
Language:English
Subjects:
Alloxan
Animals
Blood Glucose - analysis
Dental Enamel Hypoplasia - etiology
Dental Enamel Hypoplasia - pathology
Dentistry
diabetes mellitus
Diabetes Mellitus, Experimental - blood
Diabetes Mellitus, Experimental - drug therapy
Disease Models, Animal
enamel hypoplasia
Female
Hypoglycemic Agents - therapeutic use
Insulin, Isophane - therapeutic use
Male
maternal diabetes
Microscopy, Electron, Scanning
Pregnancy
Pregnancy in Diabetics - blood
Pregnancy in Diabetics - drug therapy
Rats
Rats, Wistar
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Summary:Enamel hypoplasia is an important clinical problem commonly seen in children born to diabetic women. We aimed to characterize the enamel hypoplasia in Wistar rats born to alloxan-induced diabetes mellitus rats. Groups consisted of pregnant rats supplemented (ISDR) or not (NISDR) with insulin and controls, in which sterile saline solution was administered instead of alloxan or insulin. The mandibular incisors of one-month-old rats born to these mothers were analyzed. Whitish defective enamel was found macroscopically in both experimental groups (ISDR = 37.5%, NISDR = 33.3%) but not in the control group. Mild to severe enamel hypoplasia was observed by scanning electron microscopy (ISDR = 93.8%; NISDR = 100%, control = 4.2%). The severity of hypoplasia correlated positively with the maternal level of blood glucose. In conclusion, the intensity of enamel hypoplasia in the teeth of the litter born to alloxan-induced diabetic rats was variable and was dependent on the glycemic level of the pregnant rat.
ISSN:0103-6440
0103-6440
DOI:10.1590/S0103-64402003000200003