Characterization of Vitamin D Status in Older Persons with Cognitive Impairment

Vitamin D exerts a role in the maintenance of cognitive abilities and in frailty. Although several studies evaluated the interactions between vitamin D and cognitive impairment, results were conflicting. In a cohort of community-dwelling older persons, we described the association between vitamin D...

Full description

Saved in:
Bibliographic Details
Published in:Nutrients 2022-03, Vol.14 (6), p.1142
Main Authors: Arosio, Beatrice, Rossi, Paolo Dionigi, Ferri, Evelyn, Cesari, Matteo, Vitale, Giovanni
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
Aged
Aged, 80 and over
Aging
Alzheimer's disease
Brain
Calciferol
Cognitive ability
Cognitive Dysfunction
cognitive impairment
Dementia
Dementia disorders
Electrochemiluminescence
Evaluation
Frail Elderly - psychology
Frailty
Geriatrics
Humans
Hydrocephalus
Immunoassays
Impairment
Middle Aged
Older people
Stroke
Variance analysis
Vitamin D
Vitamin deficiency
Vitamins
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Vitamin D exerts a role in the maintenance of cognitive abilities and in frailty. Although several studies evaluated the interactions between vitamin D and cognitive impairment, results were conflicting. In a cohort of community-dwelling older persons, we described the association between vitamin D levels and cognitive decline and all-cause dementia evaluating frailty's contribution. Our cohort included 509 adults, aged 64-92 years: 176 patients with mild cognitive impairment (MCI), 59 with Alzheimer's Disease (AD), 26 with idiopathic Normal Pressure Hydrocephalus (iNPH), 133 with mixed dementia (MD) and 115 without cognitive decline. Frailty was measured by frailty index, and serum 25-hydroxyvitamin D concentrations through electrochemiluminescence immunoassays. We found a significant association between vitamin D levels and Mini Mental State Examination independently of cognitive impairment, age, sex and frailty. The patients with dementia (AD and MD) showed the lowest vitamin D levels, while MCI patients showed higher levels than the other groups. The most severe deficiency was observed in MD patients, the most aged as well as cognitively and functionally impaired. In conclusion, in our community-dwelling older persons investigated for a suspected cognitive impairment, we observed an association between vitamin D levels and cognitive decline, regardless of the frailty status.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu14061142