Role and Mechanisms of Mitophagy in Liver Diseases

The mitochondrion is an organelle that plays a vital role in the regulation of hepatic cellular redox, lipid metabolism, and cell death. Mitochondrial dysfunction is associated with both acute and chronic liver diseases with emerging evidence indicating that mitophagy, a selective form of autophagy...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2020-03, Vol.9 (4), p.837
Main Authors: Ma, Xiaowen, McKeen, Tara, Zhang, Jianhua, Ding, Wen-Xing
Format: Article
Language:English
Subjects:
Adenoviruses
alcohol
Animals
Autophagy
Cell cycle
Cell death
Endoplasmic reticulum
Enzymes
Fatty liver
Hepatitis
Humans
Hypoxia
Ischemia
Lipid metabolism
Liver - metabolism
Liver - pathology
Liver diseases
Liver Diseases - pathology
Mitochondria
Mitochondria - metabolism
Mitochondria - ultrastructure
Mitophagy
NAFLD
Parkin
Phagocytosis
Phosphatase
Phosphorylation
Pink1
Proteins
Receptors, Cell Surface - metabolism
Reperfusion
Review
Signal Transduction
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Summary:The mitochondrion is an organelle that plays a vital role in the regulation of hepatic cellular redox, lipid metabolism, and cell death. Mitochondrial dysfunction is associated with both acute and chronic liver diseases with emerging evidence indicating that mitophagy, a selective form of autophagy for damaged/excessive mitochondria, plays a key role in the liver's physiology and pathophysiology. This review will focus on mitochondrial dynamics, mitophagy regulation, and their roles in various liver diseases (alcoholic liver disease, non-alcoholic fatty liver disease, drug-induced liver injury, hepatic ischemia-reperfusion injury, viral hepatitis, and cancer) with the hope that a better understanding of the molecular events and signaling pathways in mitophagy regulation will help identify promising targets for the future treatment of liver diseases.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells9040837