Novel antimicrobial coating for hernia meshes

Antibiotic coating for several medical devices has been carried out; however, there are only few studies about coating hernia meshes with antimicrobial substances. In this study we checked the capacity of different commercially available hernia meshes to act as drug carrier. The meshes were coated w...

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Bibliographic Details
Published in:Frontiers in cellular and infection microbiology 2024-10, Vol.14, p.1383680
Main Authors: Kühn, Klaus Dieter, Coraça-Huber, Débora C, Erdtmann, Michael, Bernhardt, Gerwin A, Fölsch, Christian
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Anti-Infective Agents - pharmacology
biofilm
Cellular and Infection Microbiology
Chlorhexidine - pharmacology
chlorhexidine palmitate
chlorhexidine palmitic acid
Coated Materials, Biocompatible - chemistry
Drug Carriers - chemistry
gentamicin palmitate
Gentamicins - pharmacology
hernia meshes
Humans
infection
Microscopy, Electron, Scanning
Palmitic Acid - chemistry
Surgical Mesh
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Summary:Antibiotic coating for several medical devices has been carried out; however, there are only few studies about coating hernia meshes with antimicrobial substances. In this study we checked the capacity of different commercially available hernia meshes to act as drug carrier. The meshes were coated with gentamicin palmitate, chlorhexidine palmitic acid and chlorhexidine palmitate. The coating mass and subsequent delivery rate were evaluated for gentamicin palmitate by fluorescence polarization. For Chlorhexidine coated devices the coating mass was determined by weighing. The delivery rate was determined by UV absorption (255 nm). The interaction of each mesh to the different coating substances was observed by scanning electron microscopy. 1. Certain uniformity was observed on the quantity of chlorhexidine coating the surface of each mesh used when compared with gentamicin palmitate coating. 2.We did not detect significant difference between the amounts of gentamicin palmitate released from each mesh. 3. The release of chlorhexidine palmitate and chlorhexidine palmitic acid from UltraPro™ and Mersilene™ were significantly higher (p
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2024.1383680