Pathogenicity and virulence of O'nyong-nyong virus: A less studied Togaviridae with pandemic potential

O'nyong-nyong virus (ONNV) is a neglected mosquito-borne alphavirus belonging to the family. ONNV is known to be responsible for sporadic outbreaks of acute febrile disease and polyarthralgia in Africa. As climate change increases the geographical range of known and potential new vectors, recen...

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Bibliographic Details
Published in:Virulence 2024-12, Vol.15 (1), p.2355201-2355201
Main Authors: Tong Jia Ming, Samuel, Tan Yi Jun, Katrina, Carissimo, Guillaume
Format: Article
Language:English
Subjects:
Africa - epidemiology
Alphavirus Infections - epidemiology
Alphavirus Infections - virology
Animals
epidemiology
Host-Pathogen Interactions
Humans
immunity
Mosquito Vectors - virology
O'nyong-nyong Virus - genetics
O'nyong-nyong Virus - pathogenicity
O’nyong nyong virus
Pandemics
pathology
Review
viral life cycle
Virulence
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Summary:O'nyong-nyong virus (ONNV) is a neglected mosquito-borne alphavirus belonging to the family. ONNV is known to be responsible for sporadic outbreaks of acute febrile disease and polyarthralgia in Africa. As climate change increases the geographical range of known and potential new vectors, recent data indicate a possibility for ONNV to spread outside of the African continent and grow into a greater public health concern. In this review, we summarise the current knowledge on ONNV epidemiology, host-pathogen interactions, vector-virus responses, and insights into possible avenues to control risk of further epidemics. In this review, the limited ONNV literature is compared and correlated to other findings on mainly Old World alphaviruses. We highlight and discuss studies that investigate viral and host factors that determine viral-vector specificity, along with important mechanisms that determine severity and disease outcome of ONNV infection.
ISSN:2150-5594
2150-5608
DOI:10.1080/21505594.2024.2355201