The association between serum uric acid level and heart failure and mortality in the early period of ST-elevation acute myocardial infarction

• Published in: Türk Kardiyoloji Derneği arşivi 2014-09, Vol.42 (6), p.501-508
• Main Authors: Gazi, Emine, Temiz, Ahmet, Altun, Burak, Barutçu, Ahmet, Bekler, Adem, Güngör, Omer, Yener, Ali Umit, Kurt, Tolga, Ozcan, Sedat, Gazi, Sabri
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; biological markers/blood; cardiovascular diseases/mortality; heart failure; myocardial infarction; uric acid/blood; Female; Heart Failure - blood; Heart Failure - mortality; Hospitalization; Humans; Male; Middle Aged; Myocardial Infarction - blood; Myocardial Infarction - mortality; Retrospective Studies; Risk Factors; ROC Curve; Turkey; Uric Acid - blood
• ISSN: 1016-5169; 1016-5169
• DOI: 10.5543/tkda.2014.65507

Uric acid (UA) is a strong marker of cardiovascular disease. Therefore, we aimed to determine the relationship between serum UA levels and cardiovascular events in patients in the early period of their acute myocardial infarction. This retrospective study included 586 consecutive patients with ST-elevated myocardial infarction (STEMI) who were admitted to the hospital between March 2010 and February 2012. The study population was divided into two groups; the first group included hyperuricemic patients (n=107; uric acid level >6 mg/dl in women and >7 mg/dl in men), and the second group included patients with normal UA level (n=479). Multivariate analysis was used to demonstrate the predictive value of UA levels in groups. Patients in the hyperuricemic group were older (median 66 years vs. 60 years, p=0.001), and the ratio of female patients was higher (35.5% vs. 16.9%, p=0.001). Patients with hyperuricemia had a significantly higher incidence of in-hospital cardiovascular mortality than the normal group (15.9% vs. 3.1%, p6 hours and hyperuricemia (hazard ratio (HR): 1.83, 95% confidence interval: 1.02-3.27; p=0.041) were found to be independent predictors of advanced heart failure. Hyperuricemia was found to be an independent predictor of in-hospital cardiovascular mortality in multivariate analyses (HR: 5.32, 95% confidence interval: 2.46-11.49; p=0.001). This study showed that a high serum UA level is an independent predictor of cardiovascular mortality and morbidity during the in-hospital period of STEMI.