Current Knowledge of the Mode of Action and Immunity Mechanisms of LAB-Bacteriocins

Bacteriocins produced by lactic acid bacteria (LAB-bacteriocins) may serve as alternatives for aging antibiotics. LAB-bacteriocins can be used alone, or in some cases as potentiating agents to treat bacterial infections. This approach could meet the different calls and politics, which aim to reduce...

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Bibliographic Details
Published in:Microorganisms (Basel) 2021-10, Vol.9 (10), p.2107
Main Authors: Pérez-Ramos, Adrián, Madi-Moussa, Désiré, Coucheney, Françoise, Drider, Djamel
Format: Article
Language:English
Subjects:
ABC transporter
Aging
Amino acids
Antibiotics
Antimicrobial agents
antimicrobial peptide
Apoptosis
Bacteria
Bacterial diseases
bacteriocin
Bacteriocins
Biodegradation
Biosynthesis
Cell walls
Classification
Cytoplasmic membranes
Gram-negative bacteria
Gram-positive bacteria
Immunity
Lactic acid
Lactic acid bacteria
Life Sciences
Lipids
Membranes
Mode of action
Molecular weight
Peptides
Review
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Summary:Bacteriocins produced by lactic acid bacteria (LAB-bacteriocins) may serve as alternatives for aging antibiotics. LAB-bacteriocins can be used alone, or in some cases as potentiating agents to treat bacterial infections. This approach could meet the different calls and politics, which aim to reduce the use of traditional antibiotics and develop novel therapeutic options. Considering the clinical applications of LAB-bacteriocins as a reasonable and desirable therapeutic approach, it is therefore important to assess the advances achieved in understanding their modes of action, and the resistance mechanisms developed by the producing bacteria to their own bacteriocins. Most LAB-bacteriocins act by disturbing the cytoplasmic membrane through forming pores, or by cell wall degradation. Nevertheless, some of these peptides still have unknown modes of action, especially those that are active against Gram-negative bacteria. Regarding immunity, most bacteriocin-producing strains have an immunity mechanism involving an immunity protein and a dedicated ABC transporter system. However, these immunity mechanisms vary from one bacteriocin to another.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms9102107