Effect of feeding Chinese herb medicine ageratum-liquid on intestinal bacterial translocations induced by H9N2 AIV in mice

As a low pathogenic influenza virus, avian influenza virus subtype H9N2 (H9N2 AIV) often induces high morbidity in association with secondary bacterial infections in chickens or mammals. To explore this phenomenon, the relationship between intestinal microflora changes and bacterial translocations w...

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Bibliographic Details
Published in:Virology journal 2019-02, Vol.16 (1), p.24-24, Article 24
Main Authors: Lu, Haoran, Zhang, Luxuan, Xiao, Junfang, Wu, Che, Zhang, Huanmin, Chen, Yihu, Hu, Zhengyong, Lin, Wencheng, Xie, Qingmei, Li, Hongxin
Format: Article
Language:English
Subjects:
Ageratum
Ageratum - chemistry
Ageratum-liquid
Alcohol
Animals
Antibiotics
Atrophy
Avian flu
Avian influenza
Avian influenza viruses
Bacteria
Bacterial infections
Bacterial Infections - drug therapy
Bacterial Translocation - drug effects
Care and treatment
Chinese herb medicine
Chinese herbal medicine
Coinfection - drug therapy
Degeneration
Drugs, Chinese Herbal - pharmacology
Dysbacteriosis
E coli
Epithelial cells
Escherichia coli
Gastrointestinal Microbiome
Genetic aspects
Genome, Bacterial
H9N2 avian influenzas virus
Health aspects
Herbal medicine
Infection
Infections
Influenza
Influenza A Virus, H9N2 Subtype - pathogenicity
Influenza A Virus, H9N2 Subtype - physiology
Influenza viruses
Intestinal microbiota
Intestinal microflora
Intestinal mucosa
Intestinal Mucosa - microbiology
Intestinal Mucosa - pathology
Intestinal Mucosa - virology
Intestine
Liver
Medical research
Medicine
Mesentery
Mice
Mice, Inbred BALB C
Microbiota
Microbiota (Symbiotic organisms)
Morbidity
Mucosa
Orthomyxoviridae Infections - drug therapy
Physiological aspects
Prevention
Respiration
Respiratory tract
Studies
Translocation
Translocations (Genetics)
Villus
Viral research
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Summary:As a low pathogenic influenza virus, avian influenza virus subtype H9N2 (H9N2 AIV) often induces high morbidity in association with secondary bacterial infections in chickens or mammals. To explore this phenomenon, the relationship between intestinal microflora changes and bacterial translocations was studied post H9N2 AIV challenge and post AIV infection plus Ageratum-liquid treatment. Illumina sequencing, histological examination and Neongreen-tagged bacteria were used in this study to research the microbiota composition, intestinal barrier, and bacterial translocation in six weeks of BALB/c mice. H9N2 AIV infection caused intestinal dysbacteriosis and mucosal barrier damages. Notably, the villus length was significantly reduced (p 
ISSN:1743-422X
1743-422X
DOI:10.1186/s12985-019-1131-y