Nanoliposome-Mediated Encapsulation of Chlorella Oil for the Development of a Controlled-Release Lipid-Lowering Formulation

Chlorella oil nanoliposomes (CO-NLP) were synthesized through ultrasonic injection with ethanol, and their physicochemical properties and hypolipidemic efficacy were systematically investigated. The results revealed that the mean particle size of CO-NLP was 86.90 nm and the encapsulation efficiency...

Full description

Saved in:
Bibliographic Details
Published in:Foods 2024-01, Vol.13 (1), p.158
Main Authors: Tu, Lanlan, Zeng, Jihao, Bai, Xue, Wu, Ziyun, Wu, Jinhong, Xu, Shannan
Format: Article
Language:English
Subjects:
Algae
Analysis
Anticholesteremic agents
Bioavailability
Caustic soda
Chlorella
chlorella oil
Cholesterol
Controlled release
Digestion
Efficiency
Encapsulation
Ethanol
Fatty acids
Functional foods
Functional foods & nutraceuticals
hypolipidemic activity
in vitro digestion simulation
Intestine
Lipids
Morphology
nanoliposome
Oils & fats
Oxidation
Particle size
Physicochemical properties
Product introduction
Sodium
Storage conditions
Storage stability
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chlorella oil nanoliposomes (CO-NLP) were synthesized through ultrasonic injection with ethanol, and their physicochemical properties and hypolipidemic efficacy were systematically investigated. The results revealed that the mean particle size of CO-NLP was 86.90 nm and the encapsulation efficiency (EE) was 92.84%. Storage conditions at 4 °C were conducive to the stability of CO-NLP, maintaining an EE of approximately 90% even after 10 days of storage. The release profile of CO-NLP adhered more closely to the first-order kinetic model during in vitro assessments, exhibiting a slower release rate compared to free microalgae oil. In simulated in vitro digestion experiments, lipolytic reactions of CO-NLP were observed during intestinal digestion subsequent to nanoliposome administration. Notably, the inhibitory effect of CO-NLP on cholesterol esterase activity was measured at 85.42%. Additionally, the average fluorescence intensity of nematodes in the CO-NLP group was 52.17% lower than in the control group at a CO-NLP concentration of 500 μg/mL, which suggests a pronounced lipid-lowering effect of CO-NLP. Therefore, the CO-NLP exhibited characteristics of small and uniform particle size, elevated storage stability, gradual release during intestinal digestion, and a noteworthy hypolipidemic effect. These findings designate CO-NLP as a novel lipid-lowering active product, demonstrating potential for the development of functional foods.
ISSN:2304-8158
2304-8158
DOI:10.3390/foods13010158