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LOWER ESOPHAGEAL SPHINCTER PRESSURE MEASUREMENT UNDER STANDARDIZED INSPIRATORY MANEUVEURS

Background: Through rhythmic variations, the diaphragm influence lower esophageal sphincter (LES) pressure acting as an external sphincter. LES pressure recording is characterized by increased pressure in inspiration due to contraction of the diaphragmatic crura that involves the sphincter. Aim: To...

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Published in:Arquivos brasileiros de cirurgia digestiva : ABCD 2015-07, Vol.28 (3), p.174-177
Main Authors: RIBEIRO, Jeany Borges e Silva, DIÓGENES, Esther Cristina Arruda Oliveira, BEZERRA, Patrícia Carvalho, COUTINHO, Tanila Aguiar Andrade, ALMEIDA, Cícera Geórgia Félix de, SOUZA, Miguel Ângelo Nobre e
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creator RIBEIRO, Jeany Borges e Silva
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BEZERRA, Patrícia Carvalho
COUTINHO, Tanila Aguiar Andrade
ALMEIDA, Cícera Geórgia Félix de
SOUZA, Miguel Ângelo Nobre e
description Background: Through rhythmic variations, the diaphragm influence lower esophageal sphincter (LES) pressure acting as an external sphincter. LES pressure recording is characterized by increased pressure in inspiration due to contraction of the diaphragmatic crura that involves the sphincter. Aim: To describe a method of measuring LES pressure during standardized inspiratory maneuvers with increasing loads. Methods: The study population comprised of eight healthy female volunteers (average age of 31.5 years). An esophageal high-resolution manometry and impedance system was used for measuring the LES pressure during 3-second inspiratory efforts under 12, 24 and 48 cm H2O loads (Threshold maneuvers). Results: There was a significant difference between the average maximum LES pressure and the average maximum basal LES pressure during the first (76.19±17.92 difference, p=0.0008), second (86.92±19.01 difference, p=0.0004), and third seconds of the maneuver (90.86±17.93 difference, p=0.0002), with 12, 24 and 48 cmH2O loads. Conclusion: This maneuver is a standardization of the inspiratory LES pressure and may better differentiate patients with reflux disease from healthy individuals, and may also be useful for monitoring the treatment of these patients through inspiratory muscle training. Racional: Através de variações rítmicas, o diafragma influencia a pressão do EEI, atuando como um esfíncter externo. O registro manométrico da sua pressão caracteriza-se por aumento de pressão na inspiração resultante da contração da crura diafragmática que envolve o esfíncter. Objetivo: Descrever um método de medida da pressão do esfíncter esofágico inferior (EEI) durante manobras inspiratórias padronizadas, com cargas crescentes. Métodos: Oito voluntários sadios (sexo feminino, média de idade de 31,5 anos) participaram do estudo. Uma manometria esofágica de alta resolução e impedanciometria mediram a pressão do EEI durante manobras inspiratórias com o Threshold sob cargas de 12, 24 e 48 cm H2O. Resultados: Comparando-se as médias houve diferença significativa entre a pressão máxima do EEI e a sua pressão basal máxima durante o primeiro (diferença de 76,19±17,92, p=0,0008), segundo (diferença 86,92±19,01, p=0,0004) e terceiro segundos da manobra (diferença 90,86±17,93, p=0,0002), tanto com carga de 12 cm de H2O, quanto com 24 e 48 cm. Conclusão: Esta manobra é uma padronização da pressão inspiratória do EEI e pode diferenciar melhor pacientes com doença do refluxo de indivíduos
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LES pressure recording is characterized by increased pressure in inspiration due to contraction of the diaphragmatic crura that involves the sphincter. Aim: To describe a method of measuring LES pressure during standardized inspiratory maneuvers with increasing loads. Methods: The study population comprised of eight healthy female volunteers (average age of 31.5 years). An esophageal high-resolution manometry and impedance system was used for measuring the LES pressure during 3-second inspiratory efforts under 12, 24 and 48 cm H2O loads (Threshold maneuvers). Results: There was a significant difference between the average maximum LES pressure and the average maximum basal LES pressure during the first (76.19±17.92 difference, p=0.0008), second (86.92±19.01 difference, p=0.0004), and third seconds of the maneuver (90.86±17.93 difference, p=0.0002), with 12, 24 and 48 cmH2O loads. Conclusion: This maneuver is a standardization of the inspiratory LES pressure and may better differentiate patients with reflux disease from healthy individuals, and may also be useful for monitoring the treatment of these patients through inspiratory muscle training. Racional: Através de variações rítmicas, o diafragma influencia a pressão do EEI, atuando como um esfíncter externo. O registro manométrico da sua pressão caracteriza-se por aumento de pressão na inspiração resultante da contração da crura diafragmática que envolve o esfíncter. Objetivo: Descrever um método de medida da pressão do esfíncter esofágico inferior (EEI) durante manobras inspiratórias padronizadas, com cargas crescentes. Métodos: Oito voluntários sadios (sexo feminino, média de idade de 31,5 anos) participaram do estudo. Uma manometria esofágica de alta resolução e impedanciometria mediram a pressão do EEI durante manobras inspiratórias com o Threshold sob cargas de 12, 24 e 48 cm H2O. Resultados: Comparando-se as médias houve diferença significativa entre a pressão máxima do EEI e a sua pressão basal máxima durante o primeiro (diferença de 76,19±17,92, p=0,0008), segundo (diferença 86,92±19,01, p=0,0004) e terceiro segundos da manobra (diferença 90,86±17,93, p=0,0002), tanto com carga de 12 cm de H2O, quanto com 24 e 48 cm. 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LES pressure recording is characterized by increased pressure in inspiration due to contraction of the diaphragmatic crura that involves the sphincter. Aim: To describe a method of measuring LES pressure during standardized inspiratory maneuvers with increasing loads. Methods: The study population comprised of eight healthy female volunteers (average age of 31.5 years). An esophageal high-resolution manometry and impedance system was used for measuring the LES pressure during 3-second inspiratory efforts under 12, 24 and 48 cm H2O loads (Threshold maneuvers). Results: There was a significant difference between the average maximum LES pressure and the average maximum basal LES pressure during the first (76.19±17.92 difference, p=0.0008), second (86.92±19.01 difference, p=0.0004), and third seconds of the maneuver (90.86±17.93 difference, p=0.0002), with 12, 24 and 48 cmH2O loads. Conclusion: This maneuver is a standardization of the inspiratory LES pressure and may better differentiate patients with reflux disease from healthy individuals, and may also be useful for monitoring the treatment of these patients through inspiratory muscle training. Racional: Através de variações rítmicas, o diafragma influencia a pressão do EEI, atuando como um esfíncter externo. O registro manométrico da sua pressão caracteriza-se por aumento de pressão na inspiração resultante da contração da crura diafragmática que envolve o esfíncter. Objetivo: Descrever um método de medida da pressão do esfíncter esofágico inferior (EEI) durante manobras inspiratórias padronizadas, com cargas crescentes. Métodos: Oito voluntários sadios (sexo feminino, média de idade de 31,5 anos) participaram do estudo. Uma manometria esofágica de alta resolução e impedanciometria mediram a pressão do EEI durante manobras inspiratórias com o Threshold sob cargas de 12, 24 e 48 cm H2O. Resultados: Comparando-se as médias houve diferença significativa entre a pressão máxima do EEI e a sua pressão basal máxima durante o primeiro (diferença de 76,19±17,92, p=0,0008), segundo (diferença 86,92±19,01, p=0,0004) e terceiro segundos da manobra (diferença 90,86±17,93, p=0,0002), tanto com carga de 12 cm de H2O, quanto com 24 e 48 cm. Conclusão: Esta manobra é uma padronização da pressão inspiratória do EEI e pode diferenciar melhor pacientes com doença do refluxo de indivíduos sadios, podendo também ser útil na monitorização do tratamento desses pacientes por meio do treinamento muscular inspiratório.</description><subject>Crural diaphragm</subject><subject>Esophagogastric junction pressure</subject><subject>Gastroesophageal reflux</subject><subject>Lower esophageal sphincter</subject><subject>Original</subject><subject>Threshold maneuver</subject><issn>0102-6720</issn><issn>0102-6720</issn><issn>2317-6326</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNplkd1OwkAQhTdGIwZ5BvsC6Oxu2-3emDSwQpNSSH80eLPZtluEACUtmvj2LmCIxIvJTM6Z-S7mIPSA4RE7HJ4SwED6LiNAADsAQE0Bu0J3Z-P6z9xBvbZdHVYoB5uzW9QhrkMZtuEOzcPpm4gtkUxnY38k_NBKZuMgGqRGnMUiSbJYWBPhH_pERKmVRUNjJakfDf14GLyLoRVEySyI_XQaz62JH4nsVWRxco9uKrVude-3d1H2ItLBuB9OR8HAD_uFQ8i-X7oldm2uIc-LHBQorqmrMeOMceIoz9Me9oDwQpmpIrrUZoEDZSUzJgHaRcGJW9ZqJXfNcqOab1mrpTwKdbOQqtkvi7WWNqkq84WC49y2PY051V7uccDmHTh3KsN6PrF2n_lGl4Xe7hu1voBeOtvlh1zUX9JmlFHHNQB2AhRN3baNrs63GOQhPHkMT_4Lj_4AHVuDiQ</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>RIBEIRO, Jeany Borges e Silva</creator><creator>DIÓGENES, Esther Cristina Arruda Oliveira</creator><creator>BEZERRA, Patrícia Carvalho</creator><creator>COUTINHO, Tanila Aguiar Andrade</creator><creator>ALMEIDA, Cícera Geórgia Félix de</creator><creator>SOUZA, Miguel Ângelo Nobre e</creator><general>Colégio Brasileiro de Cirurgia Digestiva</general><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150701</creationdate><title>LOWER ESOPHAGEAL SPHINCTER PRESSURE MEASUREMENT UNDER STANDARDIZED INSPIRATORY MANEUVEURS</title><author>RIBEIRO, Jeany Borges e Silva ; DIÓGENES, Esther Cristina Arruda Oliveira ; BEZERRA, Patrícia Carvalho ; COUTINHO, Tanila Aguiar Andrade ; ALMEIDA, Cícera Geórgia Félix de ; SOUZA, Miguel Ângelo Nobre e</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-d6d1649e0bbcb0a0a9e36e17977925a88e818029ca8e8f2ede9e39037d7a88203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Crural diaphragm</topic><topic>Esophagogastric junction pressure</topic><topic>Gastroesophageal reflux</topic><topic>Lower esophageal sphincter</topic><topic>Original</topic><topic>Threshold maneuver</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RIBEIRO, Jeany Borges e Silva</creatorcontrib><creatorcontrib>DIÓGENES, Esther Cristina Arruda Oliveira</creatorcontrib><creatorcontrib>BEZERRA, Patrícia Carvalho</creatorcontrib><creatorcontrib>COUTINHO, Tanila Aguiar Andrade</creatorcontrib><creatorcontrib>ALMEIDA, Cícera Geórgia Félix de</creatorcontrib><creatorcontrib>SOUZA, Miguel Ângelo Nobre e</creatorcontrib><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Arquivos brasileiros de cirurgia digestiva : ABCD</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RIBEIRO, Jeany Borges e Silva</au><au>DIÓGENES, Esther Cristina Arruda Oliveira</au><au>BEZERRA, Patrícia Carvalho</au><au>COUTINHO, Tanila Aguiar Andrade</au><au>ALMEIDA, Cícera Geórgia Félix de</au><au>SOUZA, Miguel Ângelo Nobre e</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>LOWER ESOPHAGEAL SPHINCTER PRESSURE MEASUREMENT UNDER STANDARDIZED INSPIRATORY MANEUVEURS</atitle><jtitle>Arquivos brasileiros de cirurgia digestiva : ABCD</jtitle><date>2015-07-01</date><risdate>2015</risdate><volume>28</volume><issue>3</issue><spage>174</spage><epage>177</epage><pages>174-177</pages><issn>0102-6720</issn><eissn>0102-6720</eissn><eissn>2317-6326</eissn><abstract>Background: Through rhythmic variations, the diaphragm influence lower esophageal sphincter (LES) pressure acting as an external sphincter. LES pressure recording is characterized by increased pressure in inspiration due to contraction of the diaphragmatic crura that involves the sphincter. Aim: To describe a method of measuring LES pressure during standardized inspiratory maneuvers with increasing loads. Methods: The study population comprised of eight healthy female volunteers (average age of 31.5 years). An esophageal high-resolution manometry and impedance system was used for measuring the LES pressure during 3-second inspiratory efforts under 12, 24 and 48 cm H2O loads (Threshold maneuvers). Results: There was a significant difference between the average maximum LES pressure and the average maximum basal LES pressure during the first (76.19±17.92 difference, p=0.0008), second (86.92±19.01 difference, p=0.0004), and third seconds of the maneuver (90.86±17.93 difference, p=0.0002), with 12, 24 and 48 cmH2O loads. Conclusion: This maneuver is a standardization of the inspiratory LES pressure and may better differentiate patients with reflux disease from healthy individuals, and may also be useful for monitoring the treatment of these patients through inspiratory muscle training. Racional: Através de variações rítmicas, o diafragma influencia a pressão do EEI, atuando como um esfíncter externo. O registro manométrico da sua pressão caracteriza-se por aumento de pressão na inspiração resultante da contração da crura diafragmática que envolve o esfíncter. Objetivo: Descrever um método de medida da pressão do esfíncter esofágico inferior (EEI) durante manobras inspiratórias padronizadas, com cargas crescentes. Métodos: Oito voluntários sadios (sexo feminino, média de idade de 31,5 anos) participaram do estudo. Uma manometria esofágica de alta resolução e impedanciometria mediram a pressão do EEI durante manobras inspiratórias com o Threshold sob cargas de 12, 24 e 48 cm H2O. Resultados: Comparando-se as médias houve diferença significativa entre a pressão máxima do EEI e a sua pressão basal máxima durante o primeiro (diferença de 76,19±17,92, p=0,0008), segundo (diferença 86,92±19,01, p=0,0004) e terceiro segundos da manobra (diferença 90,86±17,93, p=0,0002), tanto com carga de 12 cm de H2O, quanto com 24 e 48 cm. Conclusão: Esta manobra é uma padronização da pressão inspiratória do EEI e pode diferenciar melhor pacientes com doença do refluxo de indivíduos sadios, podendo também ser útil na monitorização do tratamento desses pacientes por meio do treinamento muscular inspiratório.</abstract><pub>Colégio Brasileiro de Cirurgia Digestiva</pub><pmid>26537140</pmid><doi>10.1590/S0102-67202015000300007</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
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subjects Crural diaphragm
Esophagogastric junction pressure
Gastroesophageal reflux
Lower esophageal sphincter
Original
Threshold maneuver
title LOWER ESOPHAGEAL SPHINCTER PRESSURE MEASUREMENT UNDER STANDARDIZED INSPIRATORY MANEUVEURS
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