Characterization of 27 mycotoxin binders and the relation with in vitro zearalenone adsorption at a single concentration

The aim of this study was to characterize 27 feed additives marketed as mycotoxin binders and to screen them for their in vitro zearalenone (ZEN) adsorption. Firstly, 27 mycotoxin binders, commercially available in Belgium and The Netherlands, were selected and characterized. Characterization was co...

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Bibliographic Details
Published in:Toxins 2015-01, Vol.7 (1), p.21-33
Main Authors: De Mil, Thomas, Devreese, Mathias, De Baere, Siegrid, Van Ranst, Eric, Eeckhout, Mia, De Backer, Patrick, Croubels, Siska
Format: Article
Language:English
Subjects:
Acidity
Adsorption
adsorption screening
Animal Feed
Binders
Cation exchange
Cations
characterization
Feed additives
Food Additives - chemistry
Food Contamination
Humic acids
Humic Substances
mycotoxin
Mycotoxins
Relative humidity
Silicates - chemistry
X-Ray Diffraction
zearalenone
Zearalenone - chemistry
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Summary:The aim of this study was to characterize 27 feed additives marketed as mycotoxin binders and to screen them for their in vitro zearalenone (ZEN) adsorption. Firstly, 27 mycotoxin binders, commercially available in Belgium and The Netherlands, were selected and characterized. Characterization was comprised of X-ray diffraction (XRD) profiling of the mineral content and d-spacing, determination of the cation exchange capacity (CEC) and the exchangeable base cations, acidity, mineral fraction, relative humidity (RH) and swelling volume. Secondly, an in vitro screening experiment was performed to evaluate the adsorption of a single concentration of ZEN in a ZEN:binder ratio of 1:20,000. The free concentration of ZEN was measured after 4 h of incubation with each of the 27 mycotoxin binders at a pH of 2.5, 6.5 and 8.0. A significant correlation between the free concentration of ZEN and both the d-spacing and mineral fraction of the mycotoxin binders was seen at the three pH levels. A low free concentration of ZEN was demonstrated using binders containing mixed-layered smectites and binders containing humic acids.
ISSN:2072-6651
2072-6651
DOI:10.3390/toxins7010021