Placental Vitamin D-Binding Protein Expression in Human Idiopathic Fetal Growth Restriction

Vitamin D-binding protein is a multifunctional serum protein with multiple actions related to normal health. Vitamin D-binding protein transports vitamin D and influences the metabolism of this key hormone but it also has additional immunomodulatory and actin-clearing properties. We investigated whe...

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Bibliographic Details
Published in:Journal of pregnancy 2017-01, Vol.2017 (2017), p.1-5
Main Authors: Georgiou, Harry M., Brennecke, Shaun Patrick, Kalionis, Bill, Yong, Hannah E. J., Chollangi, Tejasvy, Wookey, Alice F., Murthi, Padma
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Case-Control Studies
Chi-Square Distribution
Diabetes
Enzyme-Linked Immunosorbent Assay
Female
Fetal Development
Fetal Growth Retardation - metabolism
Health risk assessment
Humans
Hypertension
Inflammation
Metabolism
Metabolites
Obstetrics
Placenta
Placenta - metabolism
Preeclampsia
Pregnancy
Proteins
Studies
Vitamin D
Vitamin D-Binding Protein - metabolism
Womens health
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Summary:Vitamin D-binding protein is a multifunctional serum protein with multiple actions related to normal health. Vitamin D-binding protein transports vitamin D and influences the metabolism of this key hormone but it also has additional immunomodulatory and actin-clearing properties. We investigated whether vitamin D-binding protein expression is altered in fetal growth restriction-associated placental dysfunction. Protein was extracted from 35 placentae derived from 17 healthy control subjects and 18 gestation-matched subjects with fetal growth restriction (FGR). FGR subjects were further subdivided as idiopathic (n=9) and nonidiopathic (n=9). Vitamin D-binding protein and 25(OH) vitamin D were measured by ELISA and normalized to protein concentration. The results showed significantly reduced levels of placental vitamin D-binding protein (control versus FGR, p
ISSN:2090-2727
2090-2735
DOI:10.1155/2017/5120267